Evaluation of the presence of endothelial dysfunction in children with Henoch-Schonlein purpura in terms of doppler ultrasound

Veronika M. Dudnyk, Tatyana G. Korol

DOI: http://dx.doi.org/10.12775/PPS.2015.01.02.003

Abstract


Purpose - to assess the presence of endothelial dysfunction in children with Henoch-Schonlein purpura in terms of Doppler ultrasound. Material and methods. We examined 123 children with Henoch - Schonlein purpura from 1 to 18 years old. Assessment of functional status and vasoregulatory vascular endothelial function was performed using Doppler ultrasound using ultrasound scanner "Philips HDII XE" B-mode sensor linear format in the frequency range from 5 MHz to 15 MHz at rest. The Results. Using doppler ultrasound, we found that the endothelial dysfunction observed in all children with at Henoch - Schonlein purpura. In patients with maximum disease activity index of structural and functional state of the endothelium of the carotid and brachial arteries were 1.3 - 1.5 times more than in healthy children. Also, more severe violations of hemodynamic characteristics of blood flow in the brachial artery (speed reduction) were observed at the III degree of activity and accounted for - Vsp 34,59 ± 3,18 mm / sec, Ved 2,72 ± 0,57 mm / sec, S / D 10 15 ± 0,82.


Keywords


Henoch-Schonlein purpura; children; endothelial dysfunction; Doppler ultrasound.

Full Text:

PDF

References


Tretyakovа A.S. Schonlein Purpura - Henoch in children: clinical and diagnostic

approaches. Children's doctor. 2011; №5: 8 - 15.

Liskyna G.A., Zynoveva G.A. Some aspects of development, currents and treatment

Schonlein-Henoch disease in children. Pediatrics. 2010; №6: 131 - 136.

Shilkina N.P., Molodkina O.A., Vinogradov A.A. Changes in the vascular bed and

endothelial function in systemic vaskulіtah. Scientific - practical rheumatology. 2007; №2: 19 - 23.

Dzau V., Bernstein K., Celermaier D. et al. The relevance of tissue angiotensin-converting

enzyme manifestations in mechanistic and endpoint data. Am.J.Cardiol. 2001; №88: 1 – 20.

Chuyko N.Y. Metabolic syndrome complicated with cerebrovascular disease: a look at the

state of the problem. Medical Transport of Ukraine. 2013; №2: 79 - 83.

Sitia S., Tomasoni L., Atzeni F. et al. From endothelial dysfunction to atherosclerosis.

Autoimmun. Rev. 2010; Vol. 9(12): 830 – 834.

Collen D. The plasminogen (fibrinolytic) system. Thromb. Haemost. 1999; Vol. 82: 259 –

Sirchak ES, Futko Kh.V., Rusin VI, arch E.Y. Identification of vascular endothelial

dysfunction in patients with cirrhosis with portal hypertension and hepatorenalnym syndrome type

II. The world of medicine and biology. 2010; №2: 155.

Celermajer D., Sorensen K., Gooch V. et al. Non-invasive detection of endothelial

dysfunction in children and adult at risk of atherosclerosis. Lancet. 1992; Vol. 340: 1111 – 1115.

Rebrova O.Y. Statystycheskyy analysis of medical data. Application package prykladnыh

programs STATISTICA. M.: Media Sphere. 2003: 31.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Refbacks

  • There are currently no refbacks.


The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. Zgodnie z Rozporządzeniem ministra nauki i szkolnictwa wyższego z dnia 22 lutego 2019 r. w sprawie ewaluacji jakości działalności naukowej (w szczególności art. 12 ust. 1 pkt 1 w zw. z art. 8 pkt 2), czasopismo Pedagogy and Psychology of Sport ewaluowane jest punktacją w wysokości 5 punktów. e-ISSN: 2450-6605 Numer DOI: 10.12775/PPS Indexing: Index Copernicus Master List https://journals.indexcopernicus.com/search/journal/issue?issueId=all&journalId=46499 DOAJ ERIH Plus Polska Bibliografia Naukowa PBN Akademicka Platforma Czasopism Naukowych Google Scholar BASE CrossRef WorldCat Arianta Baidu Scholar J-Gate JournalTOCs Microsoft Academic POL-index

Partnerzy platformy czasopism