Improvement of cure after hematopoietic stem cel transplantations in children

Jan Styczyński, Robert Dębski, Anna Krenska, Krzysztof Czyżewski, Sylwia Kołtan, Ninela Irga-Jaworska, Magdalena Szalewska, Maciej Niedźwiecki, Joanna Stefanowicz, Elżbieta Adamkiewicz-Drożyńska, Marcin Płonowski, Elżbieta Leszczyńska, Maryna Krawczuk-Rybak, Tomasz Ociepa, Tomasz Urasiński, Mariusz Wysocki

DOI: http://dx.doi.org/10.12775/MBS.2016.009

Abstract


Background. Hematopoietic stem cell transplantation (HSCT) is an established procedure for many acquired and congenital disorders of the hematopoietic system, including malignancies, bone marrow failure syndromes, disorders of the immune system, and metabolic disorders.

Objective. Analysis of results of hematopoietic stem cell transplantations performed over a period of 12 years in a single pediatric center.

Patients and methods. All transplants performed between 2003 and 2015 in the Department of Pediatric Hematology and Oncology in Bydgoszcz were included in this analysis. The results of therapy with stem cell transplantation were analyzed in three time periods: 2004-2007, 2008-2011 and 2012-2015.

Results. A total number of transplants was 318, including 132 auto-HSCT and 186 allo-HSCT. Among allogeneic transplants, 68 were done from matched-sibling donor and 118 from alternative donor. The mean survival for all patients estimated by Kaplan-Meier method was 8.1 years. Probability of overall survival (pOS) after all transplants was 0.64±0.03. pOS after allo-HSCT was 0.62±0.04, and 0.67±0.05 after auto-HSCT. Overall survival for patients transplanted in the second (2008-2011) and third (2012-2015) time period was comparable both for auto- and allo-HSCT. However, it was significantly higher than for patients transplanted in the first period of time (2004-2007) for all patients, and for those undergoing auto-HSCT. In allo-HSCT patients, in spite of increase of over 20% in pOS (43% vs 66% vs 64% in respective time periods), the difference was not statistically significant.

Conclusion. Presented results of HSCT obtained in our center are comparable with those from other international registries and centers.

Keywords


hematopoietic stem cells; high-dose therapy; stem cell transplantation; children; adolescents and young adults

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References


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