Gastric Cancer screening – does it exist or not? - literature review

Maria Kalicka, Konrad Kania, Tomasz Korzec, Przemysław Raczkiewicz




Gastric cancer (GC) is one of the biggest healthcare problem in the world. Despite the fact that the incidence of this cancer has decreased recently, GC is on the fifth place of causes of morbidity and on the second place of  causes of mortality. Therefore, some countries such as Japan and South Korea have decided to establish and develop screening methods to detect GC as early as it is possible and to begin early treatment.


There are many types of screening methods such as: markers of atrophy- serum-pepsinogen test and low serum gastrin-17 concentration, barium photofluorography of mucosa or endoscopy. Upper gastrointestinal endoscopy has the highest detection rate in high-incidence areas, compared to other screening methods, because upper endoscopy makes it possible to highlight changes such as flat and non-ulcerative lesions, which are usually invisible in barium examination. An alternative to screening is the massive eradication of Helicobacter pylori. Occasionally some countries recommend genetic testing and prophylactic gastrectomy.


Despite the high incidence of GC in Asian countries, there is still a lack of data on the cost-effectiveness of mass screening for GC. The main factor influencing the profitability of screening tests for GC is the cost of upper gastrointestinal endoscopy. Moreover, the value and usefulness of the GC screening program remains controversial in many countries.


gastric cancer; gastric cancer screening; gastric cancer markers; guadlines

Full Text:



Leonardo Henry Eusebi, Andrea Telese, Giovanni Marasco, Franco Bazzoli, Rocco Maurizio Zagari: Gastric cancer prevention strategies: A global perspective; Journal of Gastroenterology and Hepatology 2020 Sep; 35(9):1495-1502.

H Tsukuma, A Oshima, H Nakahara, T Morii: Natural history of early gastric carcer: a non-concurrent, long term, follow up study; Gut, 47 (2000), pp. 618-621

Leung WK, Wu M, Kakugawa Y, Kim JJ, Yeoh K, Goh KL, et al. Screening for gastric cancer in Asia: current evidence and practice. Lancet Oncol 2008;9:279–87.

Pasechnikov V, Chukov S, Fedorov E, Kikuste I, Leja M. Gastric cancer: Prevention, screening and early diagnosis. World J Gastroenterol 2014; 20(38): 13842-13862 [PMID: 25320521 DOI: 10.3748/wjg.v20.i38.13842]

Hamashima C, Shibuya D, Yamazaki H, Inoue K, Fukao A, Saito H, et al.: The Japanese guidelines for gastric cancer screening; Jpn J Clin Oncol 2008;38:259–67.

Ren JS, Kamangar F, Qiao YL, Taylor PR, Liang H, Dawsey SM, et al.: Serum pepsinogens and risk of gastric and oesophageal cancers in the General Population Nutrition Intervention Trial cohort; Gut 2009;58:636–42.

K. Miki, M. Ichinose, N. Kawamura, et al. The significance of low serum pepsinogen levels to detect stomach cancer associated with extensive chronic gastritis in Japanese subjects; Jpn J Cancer Res, 80 (1989), pp. 111-114 ].

Qin Cao, Zhi Hua Ran, Shu Dong Xiao: Screening of atrophic gastritis and gastric cancer by serum pepsinogen, gastrin-17 and Helicobacter pylori immunoglobulin G antibodies; J Dig Dis 2007 Feb;8(1):15-22. doi: 10.1111/j.1443-9573.2007.00271.x. PMID: 17261130 DOI: 10.1111/j.1443-9573.2007.00271.x ].

Parisa Karimi, Farhad Islami, Sharmila Anandasabapathy, Neal D. Freedman and Farin Kamangar, Gastric Cancer: Descriptive Epidemiology, Risk Factors, Screening, and Prevention; DOI: 10.1158/1055-9965.EPI-13-1057 Published May 2014.]

J Parsonnet, RA Harris, HM Hack, DK Owens: Modeling cost-effectiveness of Helicobacter pylori screening to prevent gastric cancer: a mandate for clinical trials; Lancet, 348 (1996), pp. 150-154

Zhang Y, Weck MN, Schottker B, Rothenbacher D, Brenner H. Gastric parietal cell antibodies, Helicobacter pylori infection, and chronic atrophic gastritis: evidence from a large population-based study in Germany. Cancer Epidemiol Biomarkers Prev 2013;22:821–6.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism