Histostructure of the thyroid gland in the sexually mature offsprings of female rats which were exposed to passive smoking during pregnancy
DOI: http://dx.doi.org/10.12775/JEHS.2020.10.12.005
Abstract
Active smoking or passive entry of tobacco smoke into the body of a pregnant leads to the effects of nicotine on the fetus’s cells, which causes many problems of fetal development and health problems in the later life of the offspring. The researches made has conclusively proven that smoking during pregnancy contributes to the development of many endocrine disorders. The effect of tobacco smoke on the increase of leptin, C-reactive protein, decrease of adiponectin, as well as on the appearance of antibodies to islet cells of the pancreas, as the first step to the development of type 1 diabetes, was determined by epidemiological studies. In studying the effects of nicotine during lactation it was concluded that the consumption of 6 mg / kg / day of nicotine, hyperleptinemia and primary hypothyroidism develops in the newborn, and later in adulthood, all components of the metabolic syndrome. At the same time, the data on the effect of nicotine entering the mother's body and its further influence on the offspring’s thyroid gland are few. The objective: to the study histofunctional and morphometric features of the thyroid gland of both sexes offsprings born by mothers which were exposed to "passive" smoking during pregnancy. The study object: 6-month-old Wistar rats, first-generation offspring derived from control (intact) females that were exposed to tobacco smoke components in a reproduction model of "passive" smoking. Histological and morphometric changes of the thyroid gland of 6-month-old offspring of mothers in whose bodies the products of cigarette combustion entered through the respiratory tract were studied. Morphofunctional criteria of instability and changes in the microstructure of the thyroid gland of offsprings whose mothers were exposed to nicotine in postnatal life were determined. Primary apoptotic-destructive processes in parenchyma, the formation of unstructured cell fields and microfollicles allow us to consider these offsprings as a risk group for thyroid pathology in terms of additional exposure to negative factors of "passive" smoking.
Keywords
Full Text:
PDFReferences
Pieraccini G. Identification and determination of mainstream and sidestream smoke components in different brands and types of cigarettes by means
of solidphase microextraction-gas chromatography-mass spectrometry J. Chromatogr, 2008;1180:138–150.
Shilin DE, Pykov MI. Smoking and pregnancy: the effect on the thyroid gland of postpartum women and newborns in the iodine-deficient area Klin. Thyroidology, 2004; 2 (1): 23–28.
Wojtyla A. Tobacco-related foetal origin of adult diseases hypothesis – population studies in Poland. Ann. Agric. Environ. Med, 2012;19(1):117–128.
Salafia C M, Charles AK. Placenta and fetal growth restriction. Clin. Obstet. Gynecol, 2006;49(2):–236–256.
Moura, E. G. Neonatal programming of neuroimmunomodulation role of adipocytokines and neuropeptides. Neuroimmunomodulation, 2008;15:176–188.
Grun, F. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endoctinology, 2006;147:50–55.
Xie B, Palmer P. Enveronmental tobacco use and indicators of metabolic syndrome in Chinese adults Nicotine Tob. Res. 2010;12.98–206.
Skrodeniene E, Padaiga D. Skrodeniene, E. Environmental risk factors in prediction of childhood prediabetes Medicina, Kaunas. 2008;44:56–63.
Gao YJ,. Holloway AC. Prenatal exposure to nicotine causes postnatal obesity and altered perivascular adiposetis suefunction. Obes. Res. 2005;13:687–692.
Prenatal nicotine exposure and the programming of metabolic and cardiovascular disoders [Text] / E. Somm, V. M. Schwitzgebel, D. M. Vauthay [et al.] // Mol. Cell. Endocrinol. – 2009. – Vol. 304. – P. 69–77.
Somm E. Prenatal nicotine exposure alters early pancreatic islet and the adipose tissue development with consequences and the control of body weight and glucose metabolism later in life. Endocrinology. 2008;149:6289–6299.
Lisboa PC, de Olivera E. Obesity and endocrine dysfunction programmed by maternal smoking in pregnancy and lactation. Front. Physiol. 2012;19:1–9.
Pinheiro CR, Oliveira E. Developmental plasticity in adrenal function and leptin production primed by nicotine exposure during lactation: gender differences in rats. Horm. Metab. Res. 2011;43:693–701.
Article Metrics
Metrics powered by PLOS ALM
Journal of Education, Health and Sport formerly Journal of Health Sciences
Declaration on the original version.
Editors indicates that the main version of the magazine is to issue a "electronic".
The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.
1223 Journal of Education, Health and Sport eISSN 2391-8306 7
ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X
Archives 2011 - 2014
PBN 2011 - 2014
https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616
POL-index 2011 - 2014
https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655
BASE 2011 - 2014
http://elibrary.ru/contents.asp?titleid=37467
http://journal.rsw.edu.pl/index.php/JHS/issue/archive
Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.
https://zdb-katalog.de/title.xhtml?idn=1080187162
https://europub.co.uk/journals/22625
US NLM = 101679844
101679844 - NLM Catalog Result - NCBI
https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844
Find a library that holds this journal: http://worldcat.org/issn/23918306
PBN Poland
https://pbn.nauka.gov.pl/sedno-webapp/journals/49068
POL-index
https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4
BASE
Redaction, Publisher and Editorial Office
Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X
The journal has been approved for inclusion in ERIH PLUS.
The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984
Indexed in Index Copernicus Journals Master List.
http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html
ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 2011: 5.48
RG Journal Impact: 0.18 *
RG Journal impact history
2020 | Available summer 2021 |
---|---|
2018 / 2019 | 0.18 |
2017 | 0.07 |
2016 | 0.03 |
RG Journal impact over time
Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)
is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.
Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467
Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski
(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)