Quatitative morphological analysis of the venous bed of the common bile duct in postresection portal hypertension

N. Ya. Monastyrska

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.10.034


Introduction. Removal of the left and right lateral lobes of the liver in white rats leads to postresection portal hypertension, which is characterized by dilation and plethora of the hepatic portal vein, mesenteric veins, esophageal and gastric veins, veins of the anterior abdominal wall, splenomegaly, ascites.

Objective of the research: to study the features of structural reorganization of the venous bed of the common bile duct in postresection portal hypertension morphometrically.

Materials of the research and their discussion. The venous bed of the common bile duct was studied by morphometric methods in 32 laboratory white male rats, which were divided into 2 groups: 1-st group included 15 intact animals, 2-nd - 17 rats with postresection portal hypertension, which was modeled by removal of the left and right hepatic lobes. One month after the start of the experiment, rats were euthanized by bloodletting under conditions of thiopental anesthesia. Histological micropreparations were made from the common bile duct, on which the venous bed was mophometrically studied, the outer and inner diameters of veins, wall thickness, height of endotheliocytes, diameter of their nuclei, nuclear-cytoplasmic ratios in these cells, relative volume of damaged endothelial cells were measured. Quantitative indicators were processed statistically.

Results of the research and their discussion. Morphometrically it was found  that in postresection portal hypertension the outer and inner diameters of veins of the common bile duct markedly increased, their wall is thinned, the height of endothelial cells, the diameters of their nuclei decreased, the nuclear-cytoplasmic ratios in endotheliocytes were disturbed, the relative volume of damaged endothelial cells increased.

Conclusions. Resection of the left and right lateral lobes of the liver in white rats leads to postresection portal hypertension and pronounced remodeling of the venous bed of the common bile duct, which was characterized by increase of outer and inner diameters of veins, thinning of their wall, decrease of height of endotheliocytes and diameters of their nuclei, violation of nuclear-cytoplasmic ratios in endothelial cells, increase of relative volume of damaged endothelial cells.


postresection portal hypertension; veins of the common bile duct; morphometry

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Avtandilov GG. Basis of quantitative pathological anatomy. Moscow: Medicine. 2002. 240 p.

Bagriy MM, Dibrova VA, Popadynets OG. Methods of morphological research. Vinnitsa: New book. 2016. 328 p.

Dronov ОІ, Zemskov SV, Bakunets YuP. Surgical treatment of focal hepatic affection: analysis of the results and perspectives. Clinical surgery. 2016. № 1. P. 28-31.

Dzygal OF. Polyorganic insufficiency development in patients with liver cirrhosis with portal hypertension. Bulletin of Scientific Research. 2017. № 2. Р. 88-92.

Grjibovski AM, Ivanov SV, Gorbatova MA. Analysis of quantitative data in two independent samples using Statistica and SPSS software: parametric and non-parametric tests. Science & Healthcare. 2016. № 2. Р. 5-28.

Horalskyy LP, Khomych VT, Kononskyy OI. Fundamentals of histological technique and morphofunctional research methods in normal and in pathology. Zhytomyr: Polissya. 2011. 288 p.

Konovalenko SO. Morphometric analysis of structural changes in endothelial cells of arteries and veins of testes in the conditions at postresection portal hypertension. Art of Medicine. 2020. № 2 (14). P. 54-58.

Reddy SS, Civan JM. From Child-Pugh to model for end-stage liver disease: deciding who needs a liver transplant. Med. Clin. North Am. 2016. Vol. 100, Issue 3. P. 449-64.

Tatarchuk LV, Hnatiuk MS. Morphometrical evaluation of peculiarities of structural reconstruction arteries of ileum at postresection portal hypertension. Achievements of Clinical and Experimental Medicine. 2018. № 2. P. 116-121.

Volchenko IV, Lyhman VN, Skoryi DI, Shevchenko AN. Features of the extensive liver resection, taking into account the prevention of postoperative complications. Kharkiv surgical school. 2016. № 3(78). P. 35-39.

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Journal of Education, Health and Sport formerly Journal of Health Sciences

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Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

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