How the therapy for endometriosis affects the hormonal status in female infertility

N. Yu. Pedachenko, T. L. Shemelko, R. A. Tukhtarian



Aim. To determine changes in the values of pituitary and ovarian hormones in women with endometriosis-associated infertility, as well as to evaluate the impact of endometriosis therapy on hormonal parameters

Materials and Methods. Sixty-nine women with small-sized endometriomas with adenomyosis (target group) and 50 women with tubal infertility (controls) were examined. The values of pituitary (luteinizing and follicle-stimulating hormones, prolactin) and ovarian (estradiol, tubular antimullerian hormone) hormones were studied. The comparison of quantitative indicators between the studied groups of women was carried out using the Mann-Whitney U-test, the statistical significance of the results was assessed at a level of not less than 95% (risk of error not more than 5% - p <0.05).


Infertile women with endometrioma and adenomyosis have lower AMH levels than infertile women with tubal factor. Among patients with endometriosis, there is an increase in serum FSH, LH, prolactin and estradiol compared with women without endometriosis.

Dienogest moderately inhibits the secretion of FSH and LH; it has almost no effect on blood AMH and estradiol values. The use of dienogest can moderately increase the level of prolactin, It is noteworthy that these indicators are within the reference range. The use of diferelin for the treatment of endometriosis has a more active effect on the hormonal status of patients, given the decrease in such indicators as FSH and LH, AMH, estradiol and prolactin

Conclusions. Women with infertility against the background of endometriosis have minor changes in the hypothalamic-pituitary-ovarian system, which indicates the need to develop medical measures in order to correct them.

The use of dienogest compared to diferelin affects the hormonal status of patients with endometriosis to a lesser extent, given the pronounced anti-proliferative effect.


endometriosis; pituitary hormones; ovarian hormones; hypothalamic-pituitary-ovarian system; infertility; dienogest; a-GnRH; diferelin

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Benagiano G, Brosens I. The history of endometriosis. Gynecol Obstet Invest. 2014;78(1):1-9

Radzinsky VY, Orazov MR, Ivanov II, Khamoshina MB, Kostin IN, Kavteladze EV, Shustova VB. Implantation failures in women with infertility associated endometriosis. Gynecological Endocrinology. 2019. 35:sup1, 27-30, DOI:10.1080/09513590.2019.1632089

Eisenberg VH, Weil C, Chodick G, Shalev V. Epidemiology of endometriosis: a large population‐based database study from a healthcare provider with 2 million members. BJOG. 2018;125(1):55-62. doi: 10.1111/1471-0528.14711

Marchenko LA, Il’ina LM. Modern conception of endometriosis development: a review. Problemy reproduktsii. 2011;(1):61-66. (in Russian)

Yuzko AM, Yuzko ТА, Rudenko NG. Status and prospects of the use of assisted reproductive technologies in the treatment of infertility in Ukraine. Health of woman. 2013;(8):26-30. (in Ukrainian)

Ailamazian EK, Potin VV, Tarasova MA, et al, authors; Ailamazian EG, editor. Ginekologiia ot pubertata do postmenopauzy: prakticheskoe rukovodstvo dlia vrachei [Gynecology from pubertal to postmenopause: a practical guide for physicians]. 3rd ed. Moscow: Medpress-inform; 2007. 284-302 pp. (in Russian)

Cramer DW, Missner SA. The epidemiology of endometriosis. Ann N Y Acad Sci. 2002;955:11-22; discussion 34-6, 396-406

Gunin AG, Emelianov V, Tolmachev AS, Tolmacheva A. Effect of prolactin and dopaminergic drugs on uterine response to chronic estrogen exposure. Journal of Endocrinology. 2002;172:61-69

Macer ML, Taylor HS. Endometriosis and infertility: a review of the pathogenesis and treatment of endometriosis–associated infertility. Obstet Gynecol Clin North Am. 2012;39(4):535-49. doi: 10.1016/j.ogc.2012.10.002.

Marchenko LA, Il’ina LM. Modern conception of endometriosis development: a review. Problemy reproduktsii. 2011;(1):61-66. (in Russian)

Barnhart, K. et al. 2002. Effect of endometriosis on in vitro fertilization. Fertil. Steril. 77: 1148–1155

Ozkan S, Murk W, Arici A. Endometriosis and infertility: epidemiology and evidence-based treatments. Ann N Y Acad Sci. 2008;1127:92-100. doi: 10.1196/annals.1434.007

B Yılmaz Hanege, S Güler Çekıç, and B Ata. Endometrioma and ovarian reserve: effects of endometriomata per se and its surgical treatment on the ovarian reserve. Facts Views Vis Obgyn. 2019; 11(2): 151–157

Phillip A. Romanski, Paula C. Brady, Leslie V. Farland, Ann M. Thomas & Mark D. Hornstein. The effect of endometriosis on the antimüllerian hormone level in the infertile population. Journal of Assisted Reproduction and Genetics.2019;36: 1179–1184

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