The risk of developing psoriasis in alcohol-dependent patients and possible therapeutic strategies

Iga Dudek, Dorota Sokół, Tomasz Skubel, Michał Dobrzyński, Małgorzata Drozd, Jakub Czarnota, Alicja Forma, Halina Piecewicz-Szczęsna

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.08.055

Abstract


Excessive alcohol consumption significantly contributes to the damage of the nervous, cardiovascular and digestive systems. According to the latest scientific reports, excessive ethanol consumption might also contribute to an increased risk of developing skin diseases such as rosacea, porphyria cutanea tarda or psoriasis. The risk of developing psoriasis in alcohol-dependent patients is estimated at 3.1-3.4%. Among these people, in addition to the use of traditional therapeutic strategies, therapy with drugs acting on the neurotransmitter systems may constitute a potential treatment. Chronic alcohol consumption increases the activation of T lymphocytes as well as the level of tumor necrosis factor-α (TNF-α) and also stimulates the excessive proliferation of keratinocytes. These factors dysregulate the immune system, predisposing to the risk of developing psoriasis. Alcohol also interferes with signaling through neurotransmission affecting dopaminergic and serotonergic systems, which may affect the immune processes in the pathogenesis of psoriasis. The results of the research showed that the daily consumption of alcohol in an amount greater than 80 grams significantly reduces the effectiveness of treatment in psoriatic patients. Moreover, traditional drugs used in the course of psoriasis (retinoids, methotrexate, cyclosporine) may show reduced activity or even lead to toxic side effects (liver fibrosis) if alcohol is not discontinued during therapy. Treatment of psoriatic patients and coexisting alcohol dependence is a separate therapeutic problem. In addition to traditional methods, drugs that affect the neurotransmitter system may become a chance, mainly due to the influence of alcohol on these systems and modulation of the immune response, which is important in the development of psoriasis.

Keywords


psoriasis; alcohol; psoriasis treatment

Full Text:

PDF

References


Greb, J. E., Goldminz, A. M., Elder, J. T., Lebwohl, M. G., Gladman, D. D., Wu, J. J., … Gottlieb, A. B. (2016). Psoriasis. Nature Reviews Disease Primers, 2, 16082.

Parisi, R. et al. Global epidemiology of psoriasis: a systematic review of incidence and prevalence. J. Invest. Dermatol. 133, 377–385 (2013).

Boehncke, W.-H., & Schön, M. P. (2015). Psoriasis. The Lancet, 386(9997), 983–994.

Nussbaum, L., Chen, Y. L., & Ogg, G. S. (2020). Role of regulatory T cells in psoriasis pathogenesis and treatment. British Journal of Dermatology.

Armstrong AW, Read C. Pathophysiology, Clinical Presentation, and Treatment of Psoriasis: A Review. JAMA. 2020;323(19):1945-1960.

Kovitwanichkanont T, Chong AH, Foley P. Beyond skin deep: addressing comorbidities in psoriasis. Med J Aust. 2020;212(11):528-534.

Griffiths, C. E., & Barker, J. N. (2007). Pathogenesis and clinical features of psoriasis. The Lancet, 370(9583), 263–271.

Gladman, D. D. (2005). Psoriatic arthritis: epidemiology, clinical features, course, and outcome. Annals of the Rheumatic Diseases, 64(suppl_2), ii14–ii17.

Corrao, G. (2004). A meta-analysis of alcohol consumption and the risk of 15 diseases. Preventive Medicine, 38(5), 613–619.

Rusyn, I., & Bataller, R. (2013). Alcohol and toxicity. Journal of Hepatology, 59(2), 387–388.

Szabo G, Mandrekar P. A recent perspective on alcohol, immunity, and host defense. Alcohol Clin Exp Res. 2009;33(2):220-232.

Cederbaum, A. I. (2012). Alcohol Metabolism. Clinics in Liver Disease, 16(4), 667–685.

Farkas, Á., & Kemény, L. (2013). Alcohol, Liver, Systemic Inflammation and Skin: A Focus on Patients with Psoriasis. Skin Pharmacology and Physiology, 26(3), 119–126.

Farkas A, Kemeny L, Szell M, Dobozy A, BataCsorgo Z: Ethanol and acetone stimulate the proliferation of HaCaT keratinocytes: the possible role of alcohol in exacerbating psoriasis. Arch Dermatol Res 2003;295:56–62.

Higgins EM, du Vivier AW. Alcohol and the skin. Alcohol Alcohol 27(6):595-602 (1992 Nov).

Higgins EM, du Vivier AW. Cutaneous disease and alcohol misuse. Br Med Bull 50(1):85-98 (1994 Jan).

Poikolainen K, Reunala T, Karvonen J, et al. Alcohol intake: a risk factor for psoriasis in young and middle aged men? BMJ 300(6727):780-3 (1990 Mar 24).

ZHU, K.-J., ZHU, C.-Y., & FAN, Y.-M. (2012). Alcohol consumption and psoriatic risk: A meta-analysis of case-control studies. The Journal of Dermatology, 39(9), 770–773.

Qureshi, A. A., Dominguez, P. L., Choi, H. K., Han, J., & Curhan, G. (2010). Alcohol Intake and Risk of Incident Psoriasis in US Women. Archives of Dermatology, 146(12), 1364.

Gupta, M. A., Schork, N. J., Gupta, A. K., & Ellis, C. N. (1993). Alcohol intake and treatment responsiveness of psoriasis: A prospective study. Journal of the American Academy of Dermatology, 28(5), 730–732.

Poikolainen K, Karvonen J, Pukkala E. Excess mortality related to alcohol and smoking among hospital-treated patients with psoriasis. Arch Dermatol. 1999;135(12):1490-1493.

Parisi R, Webb RT, Carr MJ, Moriarty KJ, Kleyn CE, Griffiths CEM, et al. Alcohol-related mortality in patients with psoriasis: a population-based cohort study. JAMA Dermatol 2017;153:1256-62.

Farber E, Nall L. Psoriasis and alcoholism. Cutis 1994;53:21-7.

Cockerell CJ. Cutaneous manifestations of HIV infection other than Kaposi’s sarcoma: clinical and histological aspects. J Am Acad Dermatol 1990;22:1260-9.

Lim DS, Bewley A, Oon HH. Psychological Profile of Patients with Psoriasis. Ann Acad Med Singapore. 2018;47(12):516-522.

Ormerod, A. D., Campalani, E., & Goodfield, M. J. D. (2010). British Association of Dermatologists guidelines on the efficacy and use of acitretin in dermatology. British Journal of Dermatology, 162(5), 952–963.

Vena, G. A., & Cassano, N. (2012). The effects of alcohol on the metabolism and toxicology of anti-psoriasis drugs. Expert Opinion on Drug Metabolism & Toxicology, 8(8), 959–972.

Balak, D. M. W., Gerdes, S., Parodi, A., & Salgado-Boquete, L. (2020). Long-term Safety of Oral Systemic Therapies for Psoriasis: A Comprehensive Review of the Literature. Dermatology and Therapy.

Hannoodee M, Mittal M. Methotrexate. [Updated 2020 Apr 7]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2020 Jan.

Kim, N., Thrash, B., & Menter, A. (2010). Comorbidities in Psoriasis Patients. Seminars in Cutaneous Medicine and Surgery, 29(1), 10–15.

Gisondi P, Del Giglio M, Cozzi A, Girolomoni G. Psoriasis, the liver, and the gastrointestinal tract. Dermatol Ther. 2010;23(2):155-159.

Mantovani A, Gisondi P, Lonardo A, Targher G. Relationship between Non-Alcoholic Fatty Liver Disease and Psoriasis: A Novel Hepato-Dermal Axis?. Int J Mol Sci. 2016;17(2):217. Published 2016 Feb 5.

Gisondi, P., Targher, G., Zoppini, G., & Girolomoni, G. (2009). Non-alcoholic fatty liver disease in patients with chronic plaque psoriasis. Journal of Hepatology, 51(4), 758–764.

Rosenberg P, Urwitz H, Johannesson A, et al. Psoriasis patients with diabetes type 2 are at high risk of developing liver fibrosis during methotrexate treatment. J Hepatol. 2007;46(6):1111-1118.

Cassano, N., Vestita, M., Apruzzi, D., & Vena, G. A. (2011). Alcohol, psoriasis, liver disease, and anti-psoriasis drugs. International Journal of Dermatology, 50(11), 1323–1331.

European Medicines Agency. Infliximab Product Information. European Medicines Agency, 2010. http://www.ema.europa.eu/ (accessed June 30, 2011).

Kim, H. J., & Lebwohl, M. G. (2018). Biologics and Psoriasis. Dermatologic Clinics.

Nordlind K, Azmitia EC, Slominski A. The skin as a mirror of the soul: exploring the possible roles of serotonin. Exp Dermatol. 2008;17(4):301–311.

Remröd C, Lonne-Rahm S, Nordlind K. Study of substance P and its receptor neurokinin-1 in psoriasis and their relation to chronic stress and pruritus. Arch Dermatol Res. 2007;299(2):85–91.

Radosa J, Dyck W, Goerdt S, Kurzen H. The cholinergic system in guttate psoriasis with special reference to mast cells. Exp Dermatol. 2011;20(8):677–679.

Svanström C, Lonne-Rahm SB, Nordlind K. Psoriasis and alcohol. Psoriasis (Auckl). 2019;9:75-79.

Becker, H. C., & Mulholland, P. J. (2014).

Neurochemical mechanisms of alcohol withdrawal. Alcohol and the Nervous System, 133–156.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism