Current views on pathogenesis of oral complications with diabetes mellitus (literature review)

S. S. Tkachuk, O. V. Tkachuk, A. A. Galagdina, M. A. Povar, M. D. Perepeliuk

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.07.039

Abstract


The aim of the study is to analyze current views on pathogenesis of lesions of the oral mucous membrane in patients with diabetes mellitus (DM).

Conclusion. Analysis of the world scientific literature is indicative of the fact that deterioration of the blood circulation and oxidative stress underlie oral complications of DM.


Keywords


diabetes mellitus; oral complications

Full Text:

PDF

References


Sousa M.G. Clinical study of the oral manifestations and related factors in type 2 diabetics patients / M.G. Sousa, L. Costa Ade, A.G. Roncalli // Braz. J. Otorhinolaryngol. – 2011. – Vol.77, №2. – Р.145–152.

The relationship between oral health and diabetes mellitus / I.B. Lamster, E. Lalla, W.S. Borgnakke, G.W. Taylor // J. Am. Dent. Assoc. – 2008. – Vol.139, Suppl. – Р. 19–24.

Oral mucosal lesions in non oral habit diabetic patients and association of diabetes mellitus with oral precancerous lesions / R. Sainia, S. Ali Al-Maweria, D. Sainib [et al.] // Diabetes Res.Clin. Practice.– 2010.–Vol. 89, Iss.3.– P. 320-326.

Diabetes mellitus and oral mucosa alterations: prevalence and risk factors / A.S. Bastosa, A.R. Leite, R. Spin-Netoa [et al.] // Diabetes Res. Clin. Pract. – 2011. – Vol.92, №1. – Р. 100–105.

Radhika T. Diabetes mellitus and oral health / T. Radhika, R. Kannan // J. Orofac. Sci. – 2012. – Vol. 4, Iss. 1. – P. 7–10.

Straka M. Oral manifestations of diabetes mellitus and influences of periodontological treatment on diabetes mellitus / M. Straka // Bratisl. Lek. Listy. –2011– Vol.112, №7. – Р. 416–420.

Crevicular fluid matrix metalloproteinase-8, -13, and TIMP-1 levels in type 2 diabetics / L. Kardeşler, B.Biyikoğlu, S. Cetinkalp [et al.] // Oral Dis. – 2010. – Vol.16, №5. – Р. 476–481.

Association of periodontal parameters with metabolic level and systemic inflammatory markers in patients with type 2 diabetes / L. Chen, B.Wei, J. Li [et al.] // J. Periodontol. – 2010.– Vol. 81, №3. – Р. 364–371.

Sashikumar R. Salivary glucose levels and oral candida carriage in type II diabetics / R. Sashikumar, R. Kannan // Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. – 2010. – Vol.109, №5. – Р. 706–711.

Scardina G.A. Periodontal microcirculation in diabetics: an in vivo non-invasive analysis by means of videocapillaroscopy / G.A. Scardina, A. Cacioppo, P. Messina // Med. Sci. Monit. – 2012. –Vol.18, №2. – Р. 58–64.

Hanes P. J. Characteristics of inflammation common to both diabetes and periodontitis: are predictive diagnosis and targeted preventive measures possible? / P. J. Hanes, R. Krishna // EPMA J. – 2010. – Vol.1, №1.– Р. 101–116.

Erythematous Oral Candidiasis in Patients with Controlled Type II Diabetes Mellitus and Complete Dentures / C. M.-S. Arlindo, A. A. Natanael, K. C. Jorge [et al.] // Mycopathologia. – 2010. – Vol.169, №3. – Р. 215–223.

Cytokine profile in the gingival crevicular fluid of periodontitis patients with and without type 2 diabetes: a literature review / F. Javed, M. Al-Askar, K. Al-Hezaimi [et al.] // J. Periodontol.– 2012. – Vol.83, №2. – Р. 156-161.

Investigation and quantification of key periodontal pathogens in patients with type 2 diabetes / C.A. Field, M.D. Gidley, P.M. Preshaw, N. Jakubovics // J. Periodontal Res. – 2012. – Vol.47, №4. – Р. 470–478.

Gingival crevicular fluid calprotectin, osteocalcin and cross-linked N-terminal telopeptid levels in health and different periodontal diseases / S. Becerik, B.Afacan, V.Ö. Oztürk, H. Atmaca // Dis. Markers. – 2011. – Vol.31, №6. – Р. 343–352.

Periodontal ligament remodeling and alveolar bone resorption during orthodontic tooth movement in rats with diabetes / X. Li, L. Zhang, N. Wang [et al.] // Diabetes Technol. Ther. – 2010. – Vol.12, №1. – Р.65–73.

Yamamoto T.T. Orthodontic tooth movement and expression of calcium regulating hormone / T.T. Yamamoto // Clin. Calcium.– 2012. – Vol.22, №1. – Р. 91-98.

Altered fibroblast proliferation and apoptosis in diabetic gingival wounds / T. Desta, J. Li, T. Chino, D.T. Graves // J. Dent. Res. – 2010. – Vol.89, №6. – Р. 609–614.

TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1 // R.A. Kayal, M.Siqueira, J. Alblowi [et al.] // J. Bone Miner. Res. – 2010. – Vol.25, №7. – Р. 1604-1615.

King G.L. The role of inflammatory cytokines in diabetes and its complications / G.L. King // J. Periodontol.– 2008.– Vol.79, Suppl 8. – Р. 1527–1534.

Abebe W. Endothelial dysfunction in diabetes: potential application of circulating markers as advanced diagnostic and prognostic tools / W. Abebe, M. Mozaffari // EPMA J. – 2010. – Vol.1, №1. – Р. 32–45.

Yan S.F. The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature / S.F. Yan, R. Ramasamy, A.M. Schmidt // Circ. Res. –2010. – Vol.106, №5. – Р. 842–853.

Lalla E. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases / E. Lalla, P.N. Papapanou // Nat. Rev. Endocrinol. – 2011. – Vol.7, №12. – Р. 738–748.

Lipopolysaccharides from periodontopathic bacteria Porphyromonas gingivalis and Capnocytophaga ochracea are antagonists for human Toll-like receptor 4 / A. Yoshimura, T. Kaneko, Y. Kato [et al.] // Infect. Immun. – 2002. – Vol.70, №1. – Р. 218–225.

Cell activation by Porphyromonas gingivalis lipid A molecule through Toll-like receptor 4- and myeloid differentiation factor 88-dependent signaling pathway / T. Ogawa, Y. Asai, M. Hashimoto [et al.] // Int. Immunol. – 2002. – Vol.14, №1. – Р. 1325–1332.

Src kinase participates in LPS-induced activation of NADPH oxidase / J. Check, C.L.Byrd, J. Menio [et al.] // Moll. Immunol. – 2010. – Vol.47, №4. – Р. 756–762.

Streja D. Associations between inflammatory markers, traditional risk factors, and complications in patients with type 2 diabetes mellitus / D. Streja, P. Cressey, S. Rabkin // J. Diabetes Complications. – 2003. – Vol.17, №3. – Р.120–127.

Mealey S.L. Diabetes mellitus and inflammatory periodontal disease. Current opinion in endocrinology / S.L. Mealey, L.F. Fose // Curr. Opin. Endocrinol. Diabetes Obes. – 2008. – Vol.15, Iss.2. – P. 135–141.

Association between acute-phase reactants and advanced glycation end products in type 2 diabetes / K. Tan, W. Chow, S. Tam [et al.] // Diabetes Care. – 2004. – Vol.27, №1. – Р. 223–228.

Lalla E. Diabetes mellitus and periodontitis: a tale of two common interrelated diseases / E. Lalla, P.N. Papapanou // Nat. Rev. Endocrinol. – 2011. – Vol.7, №12. – Р. 738–748.

Prapulla D. Gingival Crevicular Fluid VEGF Levels in Periodontal Health and Disease / D. Prapulla, P. Sujatha, A. Pradeep // J. Periodontol. – 2007. – Vol.78, №9. – Р. 1783–1787.

Vascular endothelial growth factor (VEGF) levels of gingiva and gingival crevicular fluid in diabetic and systemically healthy periodontitis patients / E. Sakallioğlu, E.Aliyev, M. Lütfioğlu [et al.] // Clin. Oral Investig. – 2007. – Vol.11, №2. – Р. 115–120/

Yan S.F. The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature / S.F. Yan, R. Ramasamy, A.M. Schmidt // Circ. Res. –2010. – Vol.106, №5. – Р. 842–853.

Vascular endothelial growth factor (VEGF) levels of gingiva and gingival crevicular fluid in diabetic and systemically healthy periodontitis patients / E. Sakallioğlu, E.Aliyev, M. Lütfioğlu [et al.] // Clin. Oral Investig. – 2007. – Vol.11, №2. – Р. 115–120.

Vascular endothelial growth factor in gingival tissues and crevicular fluids of diabetic and healthy periodontal patients / P. Güneri, F. Ünlü, B. Yeşilbek [et al.] // J. Periodontol. – 2004. – Vol.75, №1. – Р. 91–97.

Pradhan S. Interrelationship between diabetes and periodontitis: a review / S. Pradhan, K. Goel // J. Nepal. Med. Assoc. – 2011.– Vol.51, №183.– Р. 144–153.

Efficacy of periodontal treatment on glycaemic control in diabetic patients: A meta-analysis of interventional studies / L. Darr, J.N. Vergnes, P. Gourdy, M. Sixou // Diabetes Metab. – 2008. – Vol.34, №5. – Р. 497–506.

Periodontitis and diabetes: a two-way relationship / P.M. Preshaw, A.L. Alba, D. Herrera [et al.] // Diabetologia. – 2012. – Vol.55, №1. – Р. 21-31.

Salivary biomarkers of oral health: a cross-sectional study / N. Rathnayake, S. Akerman, B. Klinge [et al.] // J. Clin. Periodontol. – 2013. – Vol.40, №2. – Р. 140–147.

Cafiero C. Predictive, preventive, personalised and participatory periodontology: «the 5Ps age» has already started / C. Cafiero, S. Matarasso // EPMA J. – 2013. – Vol.4, №1. – Р. 16.

Sheth T.S. Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy / T.S. Sheth, S.J. Verma // J. Indian Soc. Periodontol. – 2011. – Vol.15, №3. – Р. 235–239.

Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy / D. Wei, X.L. Zhang, Y.Z. Wang [et al.] // Aust. Dent. J. – 2010. – Vol.55, №1. – Р. 70–78.

Salivary antioxidants in patients with type 1 or type 2 diabetes and inflammatory periodontal disease: a case-control study // P. Gümüş, N. Buduneli, S. Cetinkalp [et al.] // J. Periodontol. – 2009. –Vol. 80, №9. – Р. 1440–1446.

Superoxide dismutase enzyme and thiol antioxidants in gingival crevicular fluid and saliva / S. Karim, P.K. Pratibha, S. Kamath [et al.] // Dent. Res. J. – 2012. – Vol.9, №3. – Р. 266–272.

Gowri P. Evaluation of Total Antioxidant Capacity of Saliva in Type 2 Diabetic Patients with and without Periodontal Disease: A Case-Control Study / P. Gowri, T. Biju, R. J. Saurabh // N. Am. J. Med. Sci. – 2013. – Vol.5, №1. – Р. 51–57.

Salivary proteomics in biomedical research / A. Zhang, H. Sun, P. Wang, X. Wang // Clin. Chim. Acta. – 2013. – Vol.415, №3. – Р. 261-265.

Defining salivary biomarkers using mass spectrometry-based proteomics: a systematic review / S.K. Al-Tarawneh, M.B. Border, C. Dibble, S. Bencharit // OMICS. – 2011. – Vol.15, №6. Р. – P. 353–361.

Gorr S.-U. Antimicrobial peptides in periodontal innate defense / S.-U. Gorr // Front. Oral Biol. – 2012. – № 15 – Р. 84–98.

Shilpashree H. S. Evaluation of salivary immunoglobulin A levels in tobacco smokers and patients with recurrent aphthous ulcers / H. S. Shilpashree, S. Sarapur // J. Natl. Sci. Biol. Med. – 2012. – Vol.3, №2. – Р. 177–181.

Saluja R. Determination of levels of salivary IgA subclasses in patients with minor recurrent aphthous ulcer / R. Saluja, A. Kale, S. Hallikerimath // J. Oral Maxillofac. Pathol. – 2012. – Vol.16, №1. – Р. 49–53.

Shilpashree H. S. Evaluation of salivary immunoglobulin A levels in tobacco smokers and patients with recurrent aphthous ulcers / H. S. Shilpashree, S. Sarapur // J. Natl. Sci. Biol. Med. – 2012. – Vol.3, №2. – Р. 177–181.

Saluja R. Determination of levels of salivary IgA subclasses in patients with minor recurrent aphthous ulcer / R. Saluja, A. Kale, S. Hallikerimath // J. Oral Maxillofac. Pathol. – 2012. – Vol.16, №1. – Р. 49–53.

Protection of the oral mucosa by salivary histatin-5 against Candida albicans in an ex vivo murine model of oral infection / B.M. Peters, J. Zhu, P.L. Jr. Fidel [et al.] // FEMS Yeast Res. – 2010. – Vol.10, № 5. – Р. 597–604.

Impaired Histatin-5 Levels and Salivary Antimicrobial Activity against C. albicans in HIV Infected Individuals / S.A. Jr. Khan, P.L. Fidel, A.A. Thunayyan // J. AIDS Clin. Res. – 2013. – Vol.4, № 193. pii: 1000193

Study of the buffering capacity, pH and salivary flow rate in type 2 well-controlled and poorly controlled diabetic patients / M.J. Bernardi, A. Reis, A.D. Loguercio [et al.] // Oral Health Prev. Dent. – 2007.– Vol.5, № 1. – P. 73–78.

Adherence to Streptococci Facilitates Fusobacterium nucleatum Integration into an Oral Microbial Community / X. He, W. Hu, C. W. Kaplan [et al.] // Microbial Ecology. – 2012. – Vol. 63, Iss.3. – Р. 532-354.

Saliva: more than just a factor in oral health / A.van Nieuw Ameronpn, E.C. Veerman, H.S. Brand // Ned. Tijdschr. Tandheelkd. – 2006. – Vol.113, № 5. – Р. 176–181.

The microbiological profiles of saliva, supragingival and subgingival plaque and dental caries in adults with and without type 2 diabetes mellitus / H.J. Teanpaisan, V. Chondsuvivatwong, C. Ratasaran, G. Dahlen // Oral microbiol. Immunol. – 2007. – Vol.22, №3. – P.175-181.

Microflora and periodontal disease / L. Scapoli, A. Girardi, A. Palmieri [et al.] // Dent. Res J. – 2012. – Vol.9, Suppl 2. – Р. 202-206.

Influence of sample type and collection method on Streptococcus mutans and Lactobacillus spp counts in the oral cavity / C. Motisuki, L.M. Lima, D.M. Spolidorio // Arch. Oral Biol. – 2005. – Vol.50, №3. – Р. 341–345.

Huang R. Bacterial interactions in dental biofilm / R. Huang, M. Li, R. L. Gregory // Virulence. – 2011. – Vol.2, №5. – Р. 435–444.

Roles of Salivary Components in Streptococcus mutans Colonization in a New Animal Model Using NOD/SCID.e2f1−/− Mice / T. Ito, T. Maeda, H. Senpuku // PLoS One. – 2012. – Vol.7, №2. – е 32063.

Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus / R.M. Bremenkamp, A.R.Caris, A.O. Jorge [et al.] // Arch. Oral Biol. – 2011. – Vol.56, №6. – Р. 549–555.

Krishnan P.A. Fungal infections of the oral mucosa / Krishnan P.A. // Indian J. Dent. Res. – 2012. – Vol.23, №5. – Р. 650–659.

Comparative study of the concentration of salivary and blood glucose in type 2 diabetic patients / A.C. Vasconcelos, M.S. Soares, P.C. Almeida, T.C. Soares // J. Oral Sci. – 2010. – Vol. 52, №2. – Р. 293–298.

Rautemaa R. Oral candidosis – clinical challenges of a biofilm disease / R. Rautemaa, G.Ramage // Crit. Rev. Microbiol.– 2011.– Vol.37,№4.– Р. 328–336.

Williams D. Pathogenesis and treatment of oral candidosis / D. Williams, M. Lewis // J. Oral Microbiol. – 2011. – Vol. 3, Suppl. – P. 10–14.

Dental caries and salivary alterations in Type I Diabetes / K. Rai, A.M. Hegde, A. Kamath, S. Shetty // J. Clin. Pediatr. Dent. – 2011. – Vol.36, №2. – Р.181–184.

Dental caries in diabetes mellitus: role of salivary flow rate and minerals / M. Jawed, S.M. Shahid, S.A. Qader, A. Azhar // J. Diabetes Complications. – 2011. – Vol.25, №3. – Р. 183-186.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18
20170.07
20160.03

RG Journal impact over time

RG Journal impact
0.180.160.140.120.100.080.060.040.02201620172018
  

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism