Тhe role of the internal use of mineral water in the complex treatment of patients with chronic viral hepatitis C with concomitant non-alcoholic fatty liver disease

Anna Izha

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.01.025

Abstract


Introduction: The use of modern drugs with direct antiviral effect allows achieving a stable virologic response (SVR) in patients with chronic hepatitis C (CHC). However, in most cases, after the elimination of HCV infection, the progression of fibrosis continues with the development of its terminal stages and adverse outcomes for patients. The presence of non-alcoholic fatty liver disease (NAFLD) in these patients significantly increases the rate of progression of fibrosis and its complications, even after reaching SVR. Therefore, the search and development of new non-drug treatment technologies for this category of patients is relevant. Aim: to study the effectiveness of mineral water intake (with a high content of bicarbonates, sodium, potassium, and silicon compounds) in the new mode of use in the complex treatment of patients with chronic hepatitis C with concomitant NAFLD. Methods: anamnestic, clinical, general clinical, biochemical (indicators of lipid metabolism, HOMA index), serological (markers of viral hepatitis C, HCV RNA PCR, qualitative and quantitative determination, genotyping), ultrasonographic studies of the digestive system and statistical methods. Results: Patients with chronic hepatitis C (genotype 1b in the phase of replication, minimal and moderate activity) with concomitant NAFLD, which had been divided into two groups, were examined. Patients of group I (control group) received a standard complex of treatment (diet therapy that corresponded to the Mediterranean diet, dosed exercise regimen, antiviral therapy - sofosbuvir (400 mg) and ledipasvir (90 mg) - 3 months). Patients of group II (the main group) additionally received an internal course intake of mineral water (MW) according to our methodology: 3 ml per kg of patient’s body weight 30-40-60 min before meals, depending on the acidity in the stomach, and the same dose after food intake, three times a day (course - 2 months, a break - 2 months, a second course - 2 months). Evaluation of the effectiveness of treatment was carried out after six months from the start of treatment. Conclusion: The results prove the feasibility and effectiveness of using MW in a doubled dosage regimen in the complex treatment of patients with chronic hepatitis C with chronic concomitant NAFLD, which was determined by improving lipid metabolism, reducing signs of insulin resistance, improving ultrasonographic signs and preventing the development of fibrotic changes in the liver.


Keywords


chronic viral hepatitis C; non-alcoholic fatty liver disease; mineral water

Full Text:

PDF

References


Zaytsev I, Potii V, Kiriienko V. Possible strategies for the implementation of WOH Program on the elimination of hepatitis C in Ukraine by 2030. Journal of Еducation, Нealth and Sport. 2018;8(6):324-335. Available from: http://www.ojs.ukw.edu.pl/index.php/johs/article/view/5602.

Stanaway J.D, Flaxman AD, Naghavi M. et al. The global burden of viral hepatitis from 1990 to 2013: findings from the Global Burden of Disease Study 2013. The Lancet. 2016 Sep; 388 (10049): 1081–1088. doi: 10.1016/S0140-6736(16)30579-7.

Klimova EA, Burnevich EZ, Chulanov VP. et al. Efficacy and safety of narlaprevir/ritonavir and daclatasvir non interferon combination in population of Russian patients with chronic hepatitis C. Terapevticheskii arkhiv. 2019;(8):67-74. doi: 10.26442/00403660.2019.08.000384.

Bailly F, Pradat P, Virlogeux V, Zoulim F. Antiviral therapy in patients with hepatitis C virus-induced cirrhosis. Dig Dis. 2015;33(4):613-23.doi:10.1159/000375359.

Lapa D, Garbuglia AR, Capobianchi MR, Del Porto P. Hepatitis C Virus Genetic Variability, Human Immune Response, and Genome Polymorphisms: Which Is the Interplay? Cells. 2019 Apr; 8(4): 305. doi: 10.3390/cells8040305.

Mallat А, Hezode С, Lotersztajn S. Environmental factors as disease accelerators during chronic hepatitis C. Journal of Hepatology. 2008;48(4): 657-665. https://doi.org/10.1016/j.jhep.2008.01.004.

Niu ZL, Zhang PA, Tong YQ. Age and gender distribution of Hepatitis C virus prevalence and genotypes of individuals of physical examination in WuHan, Central China. Springerplus. 2016; 5(1): 1557. doi: 10.1186/s40064-016-3224-z.

Esfeh JM, Ansari-Gilani K. Steatosis and hepatitis C. Gastroenterol Rep (Oxf). 2016 Feb; 4(1): 24–29. doi: 10.1093/gastro/gov040.

Bondini S, Younossi ZM. Non-alcoholic fatty liver disease and hepatitis C infection. Minerva Gastroenterol Dietol. 2006 Jun;52(2):135-43. https://www.ncbi.nlm.nih.gov/pubmed/16557185

Kralj D, Jukić LV, ljević SS, Duvnjak М, Smolić М, Čurčić IB. Hepatitis C Virus, Insulin Resistance, and Steatosis. J Clin Transl Hepatol. 2016;4(1):66-75. doi: 10.14218/JCTH.2015.00051.

Adinolfi LE, Rinaldi L, Guerrera B. et al. NAFLD and NASH in HCV Infection: Prevalence and Significance in Hepatic and Extrahepatic Manifestations. International Journal of Molecular Sciences. – 2016; 6 (17): 803. doi: 10.3390/ijms17060803.

Quattrini S, Pampaloni B, Brandi ML. Natural mineral waters: chemical characteristics and health effects. Clin Cases Miner Bone Metab. 2016;13(3):173-180. doi: 10.11138 / ccmbm / 2016.13.3.173.

Zolotareva TA, Babov KD, Nasibullin BA, Kozjavkin VI, Torohtin AM, Jushkovskaja OG. [Medical rehabilitation] Medicinskaja reabilitacija. K.: KІM; 2012. 496 s. [in Russiаn].

Mennuni G, Petraccia L, Fontana M еt al. The therapeutic activity of sulphate-bicarbonate-calcium-magnesiac mineral water in the functional disorders of the biliary tract. Clin Ter. 2014;165(5):e346–52. doi: 10.7417/CT.2014.1761.

Gushcha S.G., Nasibullin B.A., Zukow W., Volyanska V.S. Influence of mineral water on the structural and functional state of the rats kidneys with metabolic syndrome. Journal of Education, Health and Sport. 2019;9(10):11-21. doi: http://dx.doi.org/10.5281/zenodo.3466125.

Nassini R, Andrè E,Gazzieri D, De Siena G, Zanasi A,Geppetti P, Materazzi S. A bicarbonate-alkaline mineral water protects from ethanol-induced hemorrhagic gastric lesions in mice. Biol Pharm Bull. 2010;33(8):1319-23. doi:10.1248/bpb.33.1319.

Gushcha Sergey, Dragomiretska Natalia, Zabolotna Iryna, Nasibullin Boris, Izha Anna, Вadiuk Natalia, Koieva Khrystyna. Possibilities of using natural mineral waters in the treatment of patients with non-alcoholic fatty liver disease Balneo Research Journal. 2019. Vol. 10, № 4. Р. 450 — 456. http://bioclima.ro/Balneo280.pdf.

Toxqui L, Vaquero MP. An Intervention with Mineral Water Decreases Cardiometabolic Risk Biomarkers. A Crossover, Randomised, Controlled Trial with Two Mineral Waters in Moderately Hypercholesterolaemic Adults. Nutrients. 2016;8(7):Р. 400. doi:10.3390/nu8070400.

Kolodenko OV, Gushha SG, Zukow W. Possibilities of balneotherapy in patients with coronary heart disease after surgical revascularization of myocardium with concomitant diabetes Journal of Education, Health and Sport. 2016;6()6.459-468. doi: http://dx.doi.org/10.5281/zenodo.56142. [in Ukrainan].

Gushcha SG, Nasibullin BA, Рlakida АL, Volyanska VS, Gladkіy TV, Balashova IV. Hepatoprotective Action of Boric Mineral Waters in Toxic Hepatosis: Experimental Stady / Open Science Journal of Bioscience and Bioengineering. 2018;6(5):55-60. http://www.openscienceonline.com/journal/osjpp

Dragomiretskaya N. V., Zabolotnaya I. B., Migovich II. The therapeutic efficacy of natural medicinal resources in the treatment of patients with non-alcoholic fatty liver disease. Acta Balneologica. 2015;L VII, 4(142):253–256. http://actabalneologica.pl/wp-content/uploads/2018/05/AB2015-4.pdf.

Mineral healing waters. State standard technical specifications 42.10-02-96. [Valid from 1996-06-24]. Kyiv: Ministry of Health of Ukraine. 1996. 30 p. (Industry standard of Ukraine).


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

 

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism