Influence of negative redox potential on functional and biochemical processes of the kidneys at the polyuric stage of sublimate nephropathy
DOI: http://dx.doi.org/10.12775/JEHS.2020.10.01.021
Abstract
Goal. To find out the effect of water load of negative redox potential on the functional and biochemical processes of the kidneys in comparison with induced diuresis with ordinary tap water at the poliuric stage of sublimate nephropathy in hyponatric diets.
Materials and methods. In experiments on 60 white non-linear mature male rats in a hyposodium diet at the poliuric stage of sublimate nephropathy 72 hours after subcutaneous administration of sublimate at a dose of 5mg/kg per load of water with a negative redox potential (-232.0±25.12 mV) compared to induced diuresis with ordinary tap water (redox potential 88.7±18.35 mV), which ORP-meter was measured, lipid peroxidation, tissue fibrinolysis, succinate dehydrogenase activity, β-2-microglobulin reabsorption, excretory, ionoregulatory functions were studied, glomerular-tubular and tubular-tubular balance of the kidneys.
Results and discussion. According to the experience installed protective, antioxidant effects of water negative redox potential, which was manifested by the decrease in the level of diene conjugates, malonic aldehyde, the degree of swelling and damage by the ratio of K+/Na+ to the cortical substance of the kidney, improve the reabsorption of sodium ions, β-2-microglobulin in the proximal tubules with a reduction in the loss of this cation from urine by increasing the supply of electrons to the tubules of the kidneys. Improving the energy status of the proximal nephron in conditions experience increased activity of succinate dehydrogenase in the cortical portion of the kidney has led to the improvement of tissue fibrinolysis and processes glomerular-tubular and tubular-tubular balance with loss correlations, the relative water reabsorption from the glomerular filtration, absolute proximal and distal reabsorbtion of sodium ions.
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Shults MM., Pisarevskyi АМ., Polozova IP. Okislitelniy potencial. Teoria i praktika [Oxidation potential. Theory and practice]. L.: Chemistry, 1984. 168 p. (in Ukrainian).
Rohovyi YuYe, Kolesnik OV. Vpliv vodi vidiemnogo okisno-vidnovnogo potencialu na funktiu nirok u intactnich schuriv [Effect of negative redox potential water on kidney function in intact rats]. Buk. Med. Bul. 2012. V.16, № 3 (part ІІ). P. 191 -194. (in Ukrainian).
Pishak VP, Gozhenko AI, Rohovyi YuYe. et [al] Rol katepsinu D kirkovoi rechovini nirok v prignicheni proksimalnoi reabsorbtii ioniv natriu za umov massivnoi proteinurii [The role of cathepsin D cortical substance of kidneys in the inhibition of proximal reabsorption of sodium ions under conditions of massive proteinuria]. Ukrainian medical almanac, 2000; 1: 135-138. (in Ukrainian).
Gozhenko AI, Rohovyi YuYe, Fedoruk OS. et [al] “Prichovane” ushkodzenia proksimalnogo viddilu nephrona [The “hidden” damage of the proximal nephron]. Odessa med.j., 2001;5: 16-19. (in Ukrainian).
Rohovyi YuYe, Kolesnik OV. Stan klubochkovo-kanalcevogo i kanalcevo-kanalcevogo balansu za navantazenia vodoyu vidiemnogo okisno-vidnovnogo potencialu [State of the glomerular-tubular and tubular-tubular balance due to water load of negative redox potential]. Galician med. Bul. 2015. V. 22, № 4 (part 2). P. 56 – 60. (in Ukrainian).
Rohovyi YuYe, Kolesnik OV, Bocharov AV. Vpliv vodi vidiemnogo okisno-vidnovnogo potencialu na funktiu nirok v oligurichniy stadii sulemovoy nephropatii [Influence of water of negative redox potential on kidney function in the oliguric stage of sublimate nephropathy]. Journal of scientific research. 2017. № 1. P.129-133. (in Ukrainian).
Rohovyi YuYe., Zlotar OV, Filipova LO. Patophysiologia hepatorenalnogo sindromu na poliurichniy stadii sulemoviy nephropatii [Pathophysiology of hepatorenal syndrome on polunychne stage sublimate nephropathy] Chernivtsi: Medical University, 2012: 197. (in Ukrainian).
Rohovyi YuYe., Slobodian KV, Filipova LO. Patophysiologia vikovich osoblivostey funkcii nirok za umov nadlishku i deficitu ioniv natriu pri sulemoviy nephropatii [Pathophysiology of age characteristics of kidney function in conditions of excess and deficiency of sodium ions when Sublimate nephropathy]. Chernivtsi: Medical University, 2013: 200. (in Ukrainian).
Boychuk ТN., Rohovyi YuYe., Ariychuk ОІ. Patofiziologia nirok za nefrolitiazu [Pathophysiology of the kidney in nephrolithiasis]. Chernivtsi: Bukovina print, 2018. 195 p. (in Ukrainian)
Boychuk TM, Rohovyi YuYe, Popovich GB. Pathophysiologia gepatorenalnogo syndroma pri gemichniy hypoksii [Pathophysiology of the hepatorenal syndrome in hemic hypoxia]. Chernivtsi: Medical University, 2012: 192. (in Ukrainian).
Rohovyi YuYe., Ariychuk OI. Pathophysiologichniy analys functii nirok za cystatinom C pri utvoreni nirkovich konkrementiv 0.6-1.0 cm pri likuvani apparatom litotriptor Duet Magna [Pahophysiological analysis of the renal function by cystatin C in the formation of renal stones 0.6-1.0 cm in size in conditions of treatment with apparatus litotriptor Duet Magna] J. of Education, Health and Sport.,2017;6:545-553. doi: http://dx.doi.org/10.5281/zenodo.822488 http://ojs.ukw.edu.pl/index.php/johs/article/view/4584 (in Ukrainian).
Rohovyi YuYe., Ariychuk OI., Gerush OV. Patofiziologicheskiy analiz roli peregruzki nefrona belkom v povrejdenii proxsimalnogo kanalca pri nefroliyiaze s razmerom kamney 0.6-1.0 sm [Pathophyisiology analysis overload nephron protein in the proximal tubule damage in the nephrolithiasis size stones of 0.6-1.0 sm]. Journal of Education, Health and Sport. 2017; 7 (7):1325-1335. eISSN 2391-8306. doihttp://dx.doi.org/10.5281/zenodo.1250508 http://ojs.ukw.edu.pl/index.php/johs/article/view/5515 https://pbn.nauka.gov.pl/sedno-webapp/works/865738 (in Ukrainian)
Pishak VP, Gozhenko AI, Rohovyi YuYe. Tubulo-itersticiyniy sindrom [Tubulo-interstitial syndrome]. Chernivtsi: Medical Academy, 2002: 221. (in Ukrainian).
Gozhenko AI. Teoria bolezni [Disease theory]. Оdessa:Fenics, 2018: 236 с. (in Ukrainian).
Rohovyi Yu.Ye., Bоchаrоv А.V., Cоbilianska R.М. Rol аltеrnаtivnich mеtоdіv nаvchаnia pri vikladanii tеоrеtichnich tа clinichnix mеdichnich discipline [The role of alternative learning methods in teaching theoretical and clinical medical disciplines]. Medical education. 2003.№ 1.P.22-24. (in Ukrainian).
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