Possibilities of antihypertensive therapy in correction of cognitive impairment in hypertensive patients

V. A. Skybchyk, O. S. Pylypiv

DOI: http://dx.doi.org/10.12775/JEHS.2020.10.01.017

Abstract


Data regarding possibilities of antihypertensive therapy to reduce a risk of the development of new cases of cognitive impairment are contradictory. So, the purpose of the study was to analyze the effect of antihypertensive therapy onto the dynamics of cognitive functions in hypertensive patients. We examined 90 patients with stage 1 and 2 hypertension, 2-3 degrees (middle age of patients was 49,66 ± 8,74 years). Clinical and anamnestic examination, laboratory and instrumental methods of examination were done to all patients. Neuropsychological tests, as GPCOG, MMSE, Schulte tables were used to study cognitive functions. Cognitive impairment were observed in 36 patients (40%). The combination of inhibitors of angiotensin-converting enzymes (іАCE) or angiotensin II receptor blockers (ARB) + calcium channel blocker (CCB) was used as antihypertensive therapy.  While using this therapy not only the decrease and normalization of blood pressure but also improvement of cognitive functions were noticed. Particularly, in 61,29% cases patients gained obviously more points in the retesting  MMSE(p=0,003) and GPCOG(p=0,01) and almost all patients (96,77%) needed less time to fulfill tasks by Schulte tables (p=0,0001). The total sum of points by MMSE scale increased by 3,66% (p=0,003), the total score by GPCOG scale increased by 22,24% (p=0,01), and in the control execution of Schulte test patients used less time by 14,39 % in comparison with initial results (p=0,0001).


Keywords


hypertension; cognitive impairment; antihypertensive therapy

Full Text:

PDF

References


Launer LJ. Midlife blood pressure and dementia: the Honolulu-Asia agingstudy / Launer LJ., Ross GW., Petrovitch H. [etal.] //NeurobiolAging. – 2000. – Vol. 21. – P. 49-55.

LeviMarpillat N. Antihypertensive classes, cognitive decline and incidence of dementia:a network meta-analysis / LeviMarpillat N., Macquin-Mavier I., Tropeano AI., Bachoud-Levi AC., Maison P. // J Hypertens. – 2013. – Vol. 31(6). – P. 1073–1082.

Hanon O. Effects of hypertension therapy based on eprosartanon systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study / Hanon O., Berrou JP., Negre-Pages L., Goch JH., Nadhazi Z., Petrella R. [etal.] // J Hypertens. – 2008. – Vol. 26(8). –Р. 1642–1650.

Fogari R. Effects of valsartan compared with enalapril on blood pressure and cognitive function in elderly patients with essential hypertension / Fogari R., Mugellini A., Zoppi A., Marasi G., Pasotti C., Poletti L., Rinaldi A., Preti P. // European Journal of Clinical Pharmacology. – 2004. – Vol.59. – Р. 863–868

Hajjar I. Effect of antihypertensive therapy on cognitive function in early executive cognitive impairment: a double-blind randomized clinical trial / Hajjar I., Hart M., Chen Y.L., Mack W., Milberg W., Chui H.,Lipsitz L. // Arch. Intern. Med. – 2012. – Vol. 172(5). – P. 442-444.

McGuinness B. Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia / McGuinness B., Todd S., Passmore P., Bullock R. // Cochrane Database of Systematic Reviews. – 2009. – Vol.4, doi.org/10.1002/14651858.CD004034.pub2

Watfa G, Rossignol P, Kearney-Schwartz A, Fay R, Bracard S,Felblinger J, etal. Use of calcium channel blockers is associated with better cognitive performance in older hypertensive patients with subjective memory complaints. J Hypertens. 2010, № 28(12), Р. 2485–2493.

Primce M.J., Bird A.S., Blizard R.A. Is the cognitive function of alder patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council’s treatment trial of hypertension in older adults. BMJ 1996, № 312, P. 801–805.

Diz DI, Lewis K. Dahl memorial lecture: the renin-angiotensin system and aging. Hypertension. 2008, № 52(1), Р. 37–43.

Gustafson DR, Melchior L, Eriksson E, Sundh V, Blennow K, Skoog I. The ACE insertion deletion polymorphism relates to dementia by metabolic phenotype, APOEepsilon4, and age of dementia onset. Neurobiol Aging.2010, № 31(6), Р. 910–916.

Basso N, Paglia N, Stella I, de Cavanagh EM, Ferder L, del Rosario LoresArnaizM, et al. Protective effect of the inhibition of the reninangiotensin system on aging. RegulPept. 2005, № 128(3), Р. 247–252.


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

 

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism