Prognostic potential of proliferative activity index in assessing the effectiveness of complex neoadjuvant treatment of locally advanced breast cancer

O. V. Bondar



In recent years, breast cancer (breast cancer) has been the most common cancer and the most common cause of disability among women in developed countries. The aim of the study - determination of the role of Ki-67 and PCNA nuclear markers for the evaluation and prediction of the effectiveness of neoadjuvant antitumor treatment with the use of polychemotherapy in systemic (SPHT), endolymphatic (ELPHT) and selective intra-arterial (SIAPHT) variants in patients with breast cancer.

The study was conducted on the basis of materials from 90 histories of in patients with LABC luminal type B Т4А-DN0-2М0. The total sample was divided into three subgroups by parameter of route of neoadjuvant polychemotherapy (PCT): first control group, 22 patients - systemic PCT; the second control group (27 patients) - endolymphatic PCT; study group (41 patients) - selective intra-arterial PCT.

Clinical effect with qualitative changes of local status and transfer of patients to the category of those with resectable tumors appeared in 46% of women of the first control group after 6 courses of SPCT, in 59% of the second control group after 4 courses of ELPCT and in 90% of the studied group after 3 courses SIAPCT.

After systemic and endolymphatic PCT, reductions in Ki-67 and PCNA levels were determined to be insignificant (p>0.05) by the Mac-Nemar criterion χ2. For selective intra-arterial techniques, the dynamics were considered significant (p <0.05). Intergroup comparisons revealed a statistical advantage in favor of the third group for Pearson's χ2 compared to the first and second ones. In the study of the association between the fact of radical surgery and the initial marker levels, a strong prognostic property of Ki-67 and PCNA was determined up to 25% with respect to the outcome of future comprehensive treatment.

With the use of SIAPCT in the non-adjuvant treatment of breast cancer by Ki-67 and PCNA in the range of up to 25%, the tumor responds significantly better to the therapy and reaches a resectable status in a statistically significantly greater proportion in patients with LABC.


locally advanced breast cancer; systemic polychemotherapy; endolymphatic polychemotherapy; selective intra-arterial polychemotherapy; proliferative activity index; Ki-67; PCNA

Full Text:



Mahvi D.A., Liu R., Grinstaff M.W., Colson Y.L., Raut C.P. Local Cancer Recurrence: The Realities, Challenges, and Opportunities for New Therapies. CA Cancer J. Clin. 2018; 68 (6): 488-505.

Narod S.A. Personalised medicine and population health: breast and ovarian cancer. Hum. Genet. 2018; 137 (10): 769-778.

PDQ Screening and Prevention Editorial Board. PDQ Cancer Information Summaries [Internet]. National Cancer Institute (US); Bethesda (MD): Dec 18, 2019. Breast Cancer Screening (PDQ®): Health Professional Version.

Parada H., Sun X., Tse C.K., Olshan A.F., Troester M.A.. Lifestyle Patterns and Survival Following Breast Cancer in the Carolina Breast Cancer Study. Epidemiology. 2019; 30 (1): 83-92.

Stamatovic L., Susnjar S., Gavrilovic D., Minic I., Ursulovic T., Dzodic R. The influence of breast cancer subtypes on the response to anthracycline neoadjuvant chemotherapy in locally advanced breast cancer patients. J BUON. 2018; 23 (5): 1273-1280.

Saw S., Lim J., Lim S.H., Wong M., Lim C., Yap Y.S. Patterns of relapse after neoadjuvant chemotherapy in breast cancer: implications for surveillance in clinical practice. Breast Cancer Res Treat. 2019; 177 (1): 197-206.

Niazi M.K.K., Senaras C., Pennell M.,Arole V., Tozbikian G., Gurcan M.N. Relationship between the Ki67 index and its area based approximation in breast cancer. BMC Cancer. 2018; 18 (1): 867.

Guo J.L., Gu S.Q., Li Y., Zhang X.Y. Evaluation of clinical significance of endoglin expression during breast cancer and its correlation with ER and PCNA. Eur. Rev. Med. Pharmacol. Sci. 2017; 21 (23): 5402-5407.

Juríková M., Danihel L, Polák Š., Varga I. Ki67, PCNA, and MCM proteins: Markers of proliferation in the diagnosis of breast cancer. Acta Histochem. 2016; 118 (5): 544-552.

Sánchez-Muñoz A., Plata-Fernández Y.M., Fernández M., Jaén-Morago A., Fernández-Navarro M., de la Torre-Cabrera C., Ramirez-Tortosa C., Lomas-Garrido M., Llácer C., Navarro-Perez V., Alba-Conejo E., Sánchez-Rovira P. The role of immunohistochemistry in breast cancer patients treated with neoadjuvant chemotherapy: an old tool with an enduring prognostic value. Clin. Breast Cancer. 2013; 13 (2): 146-152.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism