Relationships between parameters of plasma lipoproteines profile and heart rate variability

Volodymyr Tsymbryla, Liliya Barylyak, Walery Zukow, Igor Popovych



Background. Relationships between parameters of plasma lipoproteines profile and heart rate variability (HRV) are one of the subjects of research at the Truskavetsian Scientific School of Balneology. The contradictions and ambiguities obtained results indicate that research in this area remains relevant. The purpose of this study is to analyze the canonical correlation between HRV parameters, on the one hand, and plasma lipoproteins profile parameters, on the other. Material and Methods. The object of observation were 20 volunteers: ten women and ten men aged 33-76 years without clinical diagnose but with dysfunction of neuro-endocrine-immune complex and metabolism, characteristic for premorbid state. We recorded twice electrocardiogram to assess the parameters of HRV (software and hardware complex "CardioLab+HRV"). Then we estimated plasma lipoproteines spectrum: High-, Law- and Very Law-Density Lipoproteines Cholesterol levels. Results. Found that plasma level of HD LP Cholesterol is upregulated by vagal influences, whereas sympathetic influences causes a downregulation. Constellation of HRV parameters determines its level by 17%. The VLD LP Cholesterol plasma level is upregulated by sympathetic influences and downregulated by vagal tone; determination rate is 22%. The maximum degree of sympathetic (directly) and vagus (inversely) determination was found in relation to LD LP Cholesterol plasma level (31%). In general, the state of autonomic nerve regulation determines the plasma lipid profile by 63%. Conclusion. The content of Cholesterol in the composition of lipoproteins of different density substantially subject to the regulatory influence of the autonomic nervous system.


High-, Law- and Very Law-Density Lipoproteines Cholesterol; HRV; Relationships.

Full Text:



Baevskiy RM, Ivanov GG. Heart Rate Variability: theoretical aspects and possibilities of clinical application [in Russian]. Ultrazvukovaya i funktsionalnaya diagnostika. 2001; 3: 106-127.

Berntson GG, Bigger JT jr, Eckberg DL, Grossman P, Kaufman PG, Malik M, Nagaraja HN, Porges SW, Saul JP, Stone PH, Van der Molen MW. Heart Rate Variability: Origines, methods, and interpretive caveats. Psychophysiology. 1997; 34: 623-648.

Cao Q, Jing J, Cui X, Shi H, Xue B. Sympathetic nerve innervation is required for beigeing in white fat. Physiol Rep. 2019; 7(6): e14031.

Chen SJ, Tsui PF, Chuang YP, Chiang DML, Chen LW, Liu ST et al. Carvediol ameliorates experimental atherosclerosis by regulation cholesterol efflux and exosome functions. Int J Mol Sci. 2019; 20(20): 5202.

Flyunt VR, Flyunt I-SS, Fil’ VM, Kovbasnyuk MM, Hryvnak RF, Popel SL, Zukow W. Relationships between caused by drinking of bioactive water Naftussya changes in urine lithogenicity and neuro-humoral-immune factors in humans with theirs abnormalities. Journal of Education, Health and Sport. 2017; 7(3): 11-30.

Fonarow GC, Deedwania P, Fonseca V, Nesto RW, Watson K, Tarka E et al. Differencial effects of extended-release carvediol and extended-release metoprolol on lipid profiles in patients with hypertension: Results of the Extended-release Carvediol Lipid Trial. J Am Soc Hypertens. 2009; 3(3): 210-220.

Goryachkovskiy AM. Clinical biochemi [in Russian]. Odesa. Astroprint; 1998: 608 p.

Gozhenko AI, Sydoruk NO, Babelyuk VYe, Dubkowa GI, Flyunt VR, Hubyts’kyi VYo, Zukow W, Barylyak LG, Popovych IL. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on some metabolic and biophysic parameters at humans with dysfunction of neuro-endocrine-immune complex. Journal of Education, Health and Sport. 2016; 6(12): 826-842.

Guo J, Chi Sh, Xu H, Jiu G, Qui Zh. Effects of cholesterol levels on the excitability of rat hippocampal neurons/ Mol Membr Biol. 2008; 25(3): 216-223.

Heart Rate Variability. Standards of Measurement, Physiological Interpretation, and Clinical Use. Task Force of ESC and NASPE. Circulation. 1996; 93(5): 1043-1065.

Hill JO, Wyatt HR, Peters JC. Energy balance and obesity. Circulation. 2012; 126:126-132.

Hiller G. Test for the quantitative determination of HDL cholesterol in EDTA plasma with Reflotron®. Klin Chem. 1987; 33: 895-898.

Huchko BYa. Multialternative poststressory changes in plasma atherogenity and their neuroendocrine and metabolic accompaniments at male and female rats [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(3): 88-96.

Huchko BYa, Barylyak LG. Influence of bioactive water Naftussya on plasma atherogenity and its metabolic and neuroendocrine accompaniments in rats [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(2): 62-70.

Korkushko OV, Pysaruk AV, Shatylo VB. The value of heart rate variability analysis in cardiology: age aspects [in Russian]. Circulation and Hemostase. 2009; 1-2: 127-139.

Kotelnikov SA, Nozdrachov AD, Odinak MM, Shustov EB, Kovalenko IYu, Davidenko VYu. Heart rate variability: understanding of the mechanisms [in Russian]. Fiziologiya cheloveka. 2002; 28(1): 130-143.

Kozyavkina NV. Variantes of thyrotropic effects of bioactive water Naftussya and their metabolic accompaniment [in Ukrainian]. Medical Hydrology and Rehabilitation. 2008; 6(3): 115-122.

Kozyavkina NV. Thyrotropic effects of bioactive water Naftussya at female rats and their metabolic, neuroendocrine and immune accompaniments [in Ukrainian]. Medical Hydrology and Rehabilitation. 2012; 10(4): 91-113.

Kozyavkina OV. Post-stress changes in neuro-endocrine status and metabolism in rats with different types of initial vegetative homeostasis induced by Naftussya bioactive water [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(1): 42-50.

Kozyavkina OV. State of post-stress parameters of autonomic homeostasis and endocrine, metabolic and immune status and correlation between them in rats with alternative types of pre-stress vegetative homeostasis induced by bioactive water Naftussya [in Ukrainian]. Medical Hydrology and Rehabilitation. 2009; 7(2): 40-56.

Kozyavkina OV, Kozyavkina NV, Gozhenko OA, Gozhenko AI, Barylyak LG, Popovych IL. Bioactive Water Naftussya and Neuroendocrine-Immune Complex [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2015: 349 p.

Kozyavkina OV, Vis’tak HI, Popovych IL. Factor, cаnonical and discriminant analysis of vegetotropic effects and accompanying changes in thyroide, metabolic and haemodynamic parameters at the women, caused by bioactive water Naftussya. Medical Hydrology and Rehabilitation. 2013; 11(3): 4-28.

Lee SY, Choi HK, Kim ST, Chung S, Park MK, Cho GJ et al. Cholesterol inhibits M-type K+ channels via protein kinase C dependent phosphorylation in sympathetic neurons. J Biol Chem. 2010; 285(14): 10939-10950.

Nguyen NL, Randall J, Bonfield BW, Bartness TJ. Central sympathetic innervation to visceral and subcutaneous white adipose tissue. Am J Physiol Regul Integr Comp Physiol. 2014; 306: R375-R386.

Nguyen NL, Barr CL, Ryu V, Cao Q, Xee B, Bartness TJ. Separate and shared sympathetic outflow to white and brown fat coordinately regulates thermoregulation and adipocyte recruitment. Am J Physiol Regul Integr Comp Physiol. 2017; 312: R132-R145.

Popadynets’ OO, Gozhenko AI, Zukow W, Popovych IL. Relationships between the entropies of EEG, HRV, immunocytogram and leukocytogram. Journal of Education, Health and Sport. 2019; 9(5): 651-666.

Popovych IL, Ruzhylo SV, Ivassivka SV, Aksentiychuk BI (editors). Balneocardioangiology [in Ukrainian]. Kyiv: Computerpress; 2005: 229 p.

Popovych IL, Sydoruk NO, Gozhenko AI, Zukow W. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on neuro-endocrine parameters at humans with dysadaptation. Journal of Education, Health and Sport. 2017; 7(2): 465-478.

Popovych IL, Vis’tak HI, Gumega MD, Ruzhylo SV. Vegetotropic Effects of Bioactive Water Naftussya and their Endocrine-Immune, Metabolic and Hemodynamic Accompaniments [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2014: 163 p.

Ruzhylo SV, Tserkovnyuk AV, Popopvych IL. Actotropic Effects of Balneotherapeutic Complex of Truskavets spa [in Ukrainian]. Кyiv: Computerpress; 2003: 131 p.

Seguchi H, Nakamura H, Aosaki N, Homma Y, Mikami Y, Takahashi S. Effects of carvediol on serum lipids. Eur J Clin Pharmacol. 1990; 38: S139-S142.

Sydoruk NO, Chebanenko OI, Popovych IL, Zukow W. Comparative Investigation of Physiological Activity of Water Naftussya from Truskavets’ and Pomyarky Deposits [in Ukrainian]. Kyiv: UNESCO-SOCIO; 2017: 216 p.

Sydoruk NO, Gozhenko AI, Zukow W. Modulating effects of bioactive water Naftussya from layers Truskavets’ and Pomyarky on neuro-endocrine-immune complex and metabolism at rats exposed to acute stress. Journal of Education, Health and Sport. 2016; 6(11): 715-730.

Vis’tak HI, Kozyavkina OV, Popovych IL, Zukow W. Vegetotropic effects of bioactive water Naftussya spa Truskavets’ and their thyroide, metabolic and haemodynamic accompaniments at the women. Journal of Health Sciences. 2013; 3(10): 557-582.

Wang S, Yang X. Inter-organ regulation of adipose tissue browing. Cell Mol Life Sci. 2017; 74(10): 1765-1776.

Wong GWK, Laugerotte A, Wright JM. Blood pressure lowering efficacy dual alpha and beta blockers for primaty hypertension. Cochrane Database Syst Rev. 2015; 8: CD007449.

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM

Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

POL-index 2011 - 2014

BASE 2011 - 2014

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

Find a library that holds this journal:


PBN Poland



Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at

Indexed in Index Copernicus Journals Master List.,p24782242,3.html

ICV 2019 = 100.00 ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

RG Journal Impact: 0.18 *

*This value is calculated using ResearchGate data and is based on average citation counts from work published in this journal. The data used in the calculation may not be exhaustive.

RG Journal impact history

2020Available summer 2021
2018 / 20190.18

RG Journal impact over time

RG Journal impact

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ)

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski


Partnerzy platformy czasopism