TNF-α and TNF-R-1 level in pregnancy with ecotopic pregnancy

Yu. B. Yakymchuk, A. V. Boychuk, A. Yu. Franchuk, V. I. Koptyuk, O. M. Yakymchuk

DOI: http://dx.doi.org/10.12775/JEHS.2019.09.12.015

Abstract


The aim of our work was to study the relationship of tumor necrotic factor and receptor 1 to tumor necrotic factor in physiological uterine pregnancy in the first trimester and in pregnant women with ectopic pregnancy who received different doses of cytostatic methotrexate for its treatment.

Methods and materials

We analyzed the results of special research methods and examined 30 pregnant women with advanced uterine pregnancy in the first trimester and 40 pregnant women with advanced ectopic pregnancy treated with methotrexate, depending on the dose of methotrexate patients were divided into 2 groups of 20 women. The first group (M1) received 75-100 mg (based on kg of weight) of methotrexate intramuscularly, and the second group (M2) received methotrexate at a dose of 75-100 mg twice after 7 days.

Research results

In healthy pregnant women with physiological pregnancy for 3-4 weeks, the level of TNF-α in blood neutrophils was within 2.02 ± 0.16 ng / ml and in pregnant women with ectopic pregnancy - 2.64 ± 0.19 ng / ml. In the M1 group, TNF-α level was slightly higher (5.49 ± 0.24 ng / ml, p <0.01) than in the group of women with ectopic pregnancy before treatment (2.64 ± 0.19) ng / ml, whereas in the methotrexate (M2) reintroduction group this indicator increased almost 4 times (10.30 ± 0.26 ng / ml) and in the M1 group almost 2.3 times (5.49 ± 0.24) ng / ml). The number of activated TNF-R1 neutrophils in the M1 group was (11.16 ± 0.30) ng / ml, versus (16.26 ± 0.43) ng / ml in the M2 group (p <0.05).

Conclusions

Neutrophil blood cells are sensitive cells of the body to study the assessment of the depth of action of cytostatic at the body level as a whole.

Indicators of tumor necrotic factor and receptor 1 tumor necrotic factor can be used as a marker of activity of cytotoxic action of different doses of methotrexate for the treatment of progressing ectopic pregnancy.


Keywords


ectopic pregnancy; methotrexate; tumor necrotic factor and tumor necrotic factor receptor 1

Full Text:

PDF

References


Guriev, T.D.; Sidorova, I.S. Ectopic pregnancy. Practical gynecology: Moscow, Russia,2007; p. 96.ISBN: 5-98811-060-6.

Boychuk, A.; Yakymchuk, Y. Results of operative andconservative metods oftreatment ectopic pregnancies. Actual Problems of Pediatry, Obstetrics and Gynecology 2016, 2. doi:10.11603/24116-4944.2016.2.6857.

Boychuk, A.; Kurylo, O.U.; Tolokova, T. Prevention of Adhesions in The Preservation of Reproductive Health of Women with Endometryoid Cysts.Rec. J. Pharm., Biol. Chem. Sci.2017, 8(3), 1447–1454. ISSN: 0975-8585

Boychuk, A.V.; Yakymchuk, Yu.B.; Yakymchuk, O.M.Violation of homocysteine exchange in conservative treatment of ectopic pregnancy. Collection of scientific papers of the Association of Obstetricians-gynecologists of Ukraine. Polygraph plus: Kyiv, 2014;p. 354. ISBN 978-966-8977-45-9.

Сohen, A.; Zakar, L.; Gil, Y.; Amer-Alshiek, J.; Bibi, G.; Almog, B.; Levin, I.Methotrexate success rates in progressing ectopic pregnancies: a reappraisal. Am J Obstet Gynecol., 2014, 211(2), 128.e1-5. doi:10.1016/j.ajog.2014.03.043

Tong, S.; Skubisz, M.M.; Horne, A.W. Molecular diagnostics and therapeutics for ectopic pregnancy. Mol. Hum. Reprod.2015, 21(2), 126–135. doi:10.1093/molehr/gau084.

Brady, P.C. New Evidence to Guide Ectopic Pregnancy Diagnosis and Management.Obstet Gynecol Surv.2017, 72(10), 618–625. doi:10.1097/OGX.0000000000000492.

Talwar,P.; Sandeep, K.; Naredi. N.; Duggal,B.S.; Jose,T.Systemic methotrexate: An effective alternative to surgery for management of unruptured ectopic pregnancy. Med J Armed Forces India. 2013, 69(2), 130–133.doi:10.1016/j.mjafi.2012.08.032.

Latchesar Tantchev 1,* , Andrey Kotzev 2 and Angel Yordanov 3Disturbed Interstitial Pregnancy: A First Case of Successful Treatment Using a Mini-Laparoscopic Approach Medicina 2019, 55, 215; doi:10.3390/medicina55050215


Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM




Journal of Education, Health and Sport formerly Journal of Health Sciences

Declaration on the original version.

Editors indicates that the main version of the magazine is to issue a "electronic".

The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019.

1223 Journal of Education, Health and Sport eISSN 2391-8306 7

ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

Archives 2011 - 2014

PBN 2011 - 2014

https://pbn.nauka.gov.pl/sedno-webapp/search?search&searchCategory=WORK&filter.inJournal=36616

POL-index 2011 - 2014

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-32a319c5-a850-4f44-ba70-1418a6087655

BASE 2011 - 2014

https://www.base-search.net/Search/Results?lookfor=Journal+of+Health+Sciences+%28Radom%29&type=all&oaboost=1&ling=1&name=&thes=&refid=dcrespl&newsearch=1

http://elibrary.ru/contents.asp?titleid=37467

http://journal.rsw.edu.pl/index.php/JHS/issue/archive

Indexed in Bases, Bazy indeksacyjne: ERIH Plus, Worldcat, PBN/POL-Index, ICI Journals Master List, Directory of Open Access Journals (DOAJ), ZBD, Ulrich's periodicals, Google Scholar, Polska Bibliografia Lekarska, EuroPub database, NLM Catalog Result - NCBI, BASE, Russian Sciences Index, Arianta.

https://zdb-katalog.de/title.xhtml?idn=1080187162

https://europub.co.uk/journals/22625

US NLM = 101679844

101679844 - NLM Catalog Result - NCBI

https://www.ncbi.nlm.nih.gov/nlmcatalog/101679844

Find a library that holds this journal: http://worldcat.org/issn/23918306

 

PBN Poland

https://pbn.nauka.gov.pl/sedno-webapp/journals/49068

POL-index

https://pbn.nauka.gov.pl/polindex-webapp/browse/journal/journal-c39c8169-88d2-45db-9e7f-d948ce9981c4

BASE

https://www.base-search.net/Search/Results?join=AND&bool0[]=AND&lookfor0[]=2391-8306&type0[]=all&page=11&l=pl&oaboost=1&refid=dcpagepl

Redaction, Publisher and Editorial Office

Publisher and Editorial Office
Department of Physical Culture,
Faculty of Earth Sciences and Spatial Management,
Nicolaus Copernicus University in Toruń, Poland
Address: Str. Lwowska 1, 87-100 Toruń, Poland

  Open Access ISSN 2391-8306 formerly ISSN: 1429-9623 / 2300-665X

The journal has been approved for inclusion in ERIH PLUS.

The ERIH PLUS listing of the journal is available at https://dbh.nsd.uib.no/publiseringskanaler/erihplus/periodical/info?id=485984

Indexed in Index Copernicus Journals Master List.

http://journals.indexcopernicus.com/Journal+of+Education+Health+and+Sport,p24782242,3.html

ICV 2018 = 95.95 ICV 2017 = 91.30 ICV 2016 = 84.69 ICV 2015 = 93.34 ICV 2014 = 89.51 Standardized Value: 8.27 ICV 2013: 7.32 ICV 2012: 6.41 ICV 20115.48

 

Indexed in Polish Scholarly Bibliography (PBN) (PBN Polska Bibliografia Naukowa) (https://pbn.nauka.gov.pl/journals/36616)

is a portal of the Polish Ministry of Science and Higher Education, collecting information on publications of Polish scientists and on Polish and foreign scholarly journals. Polish Scholarly Bibliograhpy is a part of POL-on - System of Information on Higher Education. It is operated by the Interdisciplinary Centre for Mathematical and Computational Modelling, University of Warsaw.

Indexed in Russian Sciences Index Российский индекс научного цитирования (РИНЦ) http://elibrary.ru/contents.asp?titleid=37467

Indexed in Arianta Polish scientific and professional electronic journals Aneta Drabek i Arkadiusz Pulikowski

(http://www1.bg.us.edu.pl/bazy/czasopisma/czasop_full.asp?id=3595)

Partnerzy platformy czasopism