Diagnostic and genetic markers associated with pulmonary tuberculosis in HIV-infected individuals
DOI:
https://doi.org/10.12775/JEHS.2021.11.07.022Keywords
HIV infection, tuberculosis, coinfection, biomarkers of inflammation, genetic markers, diagnosisAbstract
An important aspect of monitoring, further timely and effective treatment of HIV-TB coinfection is timely and correct diagnosis based on comprehensive clinical, laboratory and instrumental studies. Many factors play a role in the development of tuberculosis in HIV-infected people, but the key and quite important elements are the study of genetic markers and biomarkers of inflammation. A number of studies have been carried out on inflammatory markers, but IL-6, INF-γ, MIG, CRP, IL-18 remain relevant and insufficiently studied in coinfection. A comprehensive study of them will be important in the screening of HIV-TB coinfection). Determining the presence of (SNP) rs4331426 located in chromosome 18q11.2 in HIV-infected and AIDS patients will solve the issue of predisposition to the development of tuberculosis in the early stages of HIV infection and contribute to the development of further tactics of patients treatment and management.References
World Health Organization website. URL: https://www.who.int/ru/news-room/fact-sheets/detail/hiv-aids (date of application 03.03.2021).
http://medstat.gov.ua/ukr/MMXIX.html
[Latent tuberculosis infection: updated and consolidated guidelines for programmatic management]. Geneva: World Health Organization; 2018. License: CC BY-NC-SA 3.0 IGO.
Tornheim JA, Dooley KE. Tuberculosis Associated with HIV Infection. Microbiol Spectr. 2017 Jan;5(1). doi: 10.1128/microbiolspec.TNMI7-0028-2016. PMID: 28233512.
Yoon C, Semitala FC, Atuhumuza E, Katende J, Mwebe S, Asege L, Armstrong DT, Andama AO, Dowdy DW, Davis JL, Huang L, Kamya M, Cattamanchi A. Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study. Lancet Infect Dis. 2017 Dec;17(12):1285-1292. doi: 10.1016/S1473-3099(17)30488-7. Epub 2017 Aug 25. PMID: 28847636; PMCID: PMC5705273.
Tenforde MW, Yadav A, Dowdy DW, Gupte N, Shivakoti R, Yang WT, Mwelase N, Kanyama C, Pillay S, Samaneka W, Santos B, Poongulali S, Tripathy S, Riviere C, Berendes S, Lama JR, Cardoso SW, Sugandhavesa P, Christian P, Semba RD, Campbell TB, Gupta A; NWCS319 and ACTG 5175 study team. Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study. J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):e71-e79. doi: 10.1097/QAI.0000000000001308. PMID: 28169875; PMCID: PMC5472489.
Qu HQ, Fisher-Hoch SP, McCormick JB. Knowledge gaining by human genetic studies on tuberculosis susceptibility. J Hum Genet. 2011 Mar;56(3):177-82. doi: 10.1038/jhg.2010.164. Epub 2010 Dec 23. PMID: 21179108; PMCID: PMC3169186.
Lee, S. -., Lin, C. -., Chuang, T. -., Huang, H. -., Kao, Y. -., & Wu, L. S. -. (2016). SNP rs4331426 in 18q11.2 is associated with susceptibility to tuberculosis among female han taiwanese. Journal of Microbiology, Immunology and Infection, 49(3), 436-438. doi:10.1016/j.jmii.2014.11.007
de Sá NBR, Ribeiro-Alves M, da Silva TP, Pilotto JH, Rolla VC, Giacoia-Gripp CBW, Scott-Algara D, Morgado MG, Teixeira SLM. Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB/HIV-immune reconstitution inflammatory syndrome outcomes. BMC Infect Dis. 2020 Jan 20;20(1):59. doi: 10.1186/s12879-020-4786-5. PMID: 31959123; PMCID: PMC6971853.
Du Bruyn E, Wilkinson RJ. The Immune Interaction between HIV-1 Infection and Mycobacterium tuberculosis. Microbiol Spectr. 2016 Dec;4(6). doi: 10.1128/microbiolspec.TBTB2-0012-2016. PMID: 28084192.
Binay UD, Fincancı M, Fersan E, Karakeçili F. HIV ile Enfekte Hastalarda Latent Tüberküloz Enfeksiyonunu (LTBE) Belirlemede Tüberkülin Deri Testi (TDT) ve T-SPOT.TB Testlerinin Karşılaştırılması [Comparison of Tuberculin Skin Test (TST) and T-SPOT.TB Tests for Diagnosis of Latent Tuberculosis Infection (LTBI) in HIV-infected Patients]. Mikrobiyol Bul. 2019 Oct;53(4):388-400. Turkish. doi: 10.5578/mb.68601. PMID: 31709936.
Abubakar I, Jackson C, Rangaka MX. C-Tb: a latent tuberculosis skin test for the 21st century? Lancet Respir Med. 2017 Apr;5(4):236-237. doi: 10.1016/S2213-2600(17)30012-7. Epub 2017 Feb 1. PMID: 28159607.
Aggerbeck H, Ruhwald M, Hoff ST, Borregaard B, Hellstrom E, Malahleha M, Siebert M, Gani M, Seopela V, Diacon A, Lourens M, Andersen P, Dheda K. C-Tb skin test to diagnose Mycobacterium tuberculosis infection in children and HIV-infected adults: A phase 3 trial. PLoS One. 2018 Sep 24;13(9):e0204554. doi: 10.1371/journal.pone.0204554. PMID: 30248152; PMCID: PMC6152999.
Hasan T, Au E, Chen S, Tong A, Wong G. Screening and prevention for latent tuberculosis in immunosuppressed patients at risk for tuberculosis: a systematic review of clinical practice guidelines. BMJ Open. 2018 Sep 12;8(9):e022445. doi: 10.1136/bmjopen-2018-022445. PMID: 30209157; PMCID: PMC6144320.
Lustova TV, Kirilova TV, Kuzhko MM. Latent tuberculosis infection: possibilities of the quantiferon test. Aktual'naâ Infektologiâ. 2018;6(4):172-179. doi: 10.22141/2312-413x.6.3.2018.142468.
Adams S, Ehrlich R, Baatjies R, Dendukuri N, Wang Z, Dheda K. Evaluating Latent Tuberculosis Infection Test Performance Using Latent Class Analysis in a TB and HIV Endemic Setting. Int J Environ Res Public Health. 2019 Aug 14;16(16):2912. doi: 10.3390/ijerph16162912. PMID: 31416206; PMCID: PMC6720895.
Petruccioli E, Chiacchio T, Navarra A, Vanini V, Cuzzi G, Cimaglia C, Codecasa LR, Pinnetti C, Riccardi N, Palmieri F, Antinori A, Goletti D. Effect of HIV-infection on QuantiFERON-plus accuracy in patients with active tuberculosis and latent infection. J Infect. 2020 May;80(5):536-546. doi: 10.1016/j.jinf.2020.02.009. Epub 2020 Feb 22. PMID: 32097688.
Manngo PM, Gutschmidt A, Snyders CI, Mutavhatsindi H, Manyelo CM, Makhoba NS, Ahlers P, Hiemstra A, Stanley K, McAnda S, Kidd M, Malherbe ST, Walzl G, Chegou NN. Prospective evaluation of host biomarkers other than interferon gamma in QuantiFERON Plus supernatants as candidates for the diagnosis of tuberculosis in symptomatic individuals. J Infect. 2019 Sep;79(3):228-235. doi: 10.1016/j.jinf.2019.07.007. Epub 2019 Jul 15. PMID: 31319143; PMCID: PMC6692655
Abilbayeva A, Kuashova D, Bitanova E, Tarabayeva A, Shuralev EA, Bartoloni A, D'Elios MM. LIOFeron®TB/LTBI: A novel and reliable test for LTBI and tuberculosis. Int J Infect Dis. 2020 Feb;91:177-181. doi: 10.1016/j.ijid.2019.12.012. Epub 2019 Dec 23. PMID: 31877486
Della Bella C, Spinicci M, Alnwaisri HFM, Bartalesi F, Tapinassi S, Mencarini J, Benagiano M, Grassi A, D'Elios S, Troilo A, Abilbayeva A, Kuashova D, Bitanova E, Tarabayeva A, Shuralev EA, Bartoloni A, D'Elios MM. LIOFeron®TB/LTBI: A novel and reliable test for LTBI and tuberculosis. Int J Infect Dis. 2020 Feb;91:177-181. doi: 10.1016/j.ijid.2019.12.012. Epub 2019 Dec 23. PMID: 31877486.
Klautau GB, da Mota NVF, Salles MJC, Burattini MN, Rodrigues DS. Interferon-γ release assay as a sensitive diagnostic tool of latent tuberculosis infection in patients with HIV: a cross-sectional study. BMC Infect Dis. 2018 Nov 19;18(1):585. doi: 10.1186/s12879-018-3508-8. PMID: 30453903; PMCID: PMC6245697.
Overton K, Varma R, Post JJ. Comparison of Interferon-γ Release Assays and the Tuberculin Skin Test for Diagnosis of Tuberculosis in Human Immunodeficiency Virus: A Systematic Review. Tuberc Respir Dis (Seoul). 2018 Jan;81(1):59-72. doi: 10.4046/trd.2017.0072. Epub 2017 Dec 13. PMID: 29256218; PMCID: PMC5771747.
Tsiko O.V., Kozko V.M. Pulmonary lesions in HIV-positive individuals (brief overview). Aktual'naâ Infektologiâ. 2018;6(6):320-326. doi: 10.22141/2312-413x.6.6.2018.151480
Feshchenko Y. I. UP-TO-DATE TENDENCIES IN TUBERCULOSIS RESEARCH. Ukr. Pulmonol. J. 2019;1:8–24. DOI: 10.312.15/2306-4927-2019-103-1-8-24.
V. P. Melnyk, T. H. Khursa, Ya. О. Yakymova, G. Ya. Soloninka. Analysis of peculiarities of identification, diagnostics and course of tuberculosis in patients with tuberculosis/HIV co-infection. Zaporozhye medical journal 2017; 19 (5), 604–608. 10.14739/2310-1210. 2017.5.110163.
Tenforde MW, Yadav A, Dowdy DW, Gupte N, Shivakoti R, Yang WT, Mwelase N, Kanyama C, Pillay S, Samaneka W, Santos B, Poongulali S, Tripathy S, Riviere C, Berendes S, Lama JR, Cardoso SW, Sugandhavesa P, Christian P, Semba RD, Campbell TB, Gupta A; NWCS319 and ACTG 5175 study team. Vitamin A and D Deficiencies Associated With Incident Tuberculosis in HIV-Infected Patients Initiating Antiretroviral Therapy in Multinational Case-Cohort Study. J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):e71-e79. doi: 10.1097/QAI.0000000000001308. PMID: 28169875; PMCID: PMC5472489.
Yoon C, Semitala FC, Atuhumuza E, Katende J, Mwebe S, Asege L, Armstrong DT, Andama AO, Dowdy DW, Davis JL, Huang L, Kamya M, Cattamanchi A. Point-of-care C-reactive protein-based tuberculosis screening for people living with HIV: a diagnostic accuracy study. Lancet Infect Dis. 2017 Dec;17(12):1285-1292. doi: 10.1016/S1473-3099(17)30488-7. Epub 2017 Aug 25. PMID: 28847636; PMCID: PMC5705273.
М.M. Savula, O.V. Vasylyshyn. RESULTS OF TESTING OF TUBERCULOSIS BIOMARKER LIPOARABOMANNAN (LAM) IN HOSPITALIZED TUBERCULOSIS PATIENTS. INFECTIOUS DISEASES 1(99)2020. DOI 10.11603/1681-2727.2020.1.11095.
Huerga H, Rucker SCM, Bastard M, Dimba A, Kamba C, Amoros I, Szumilin E. Should Urine-LAM Tests Be Used in TB Symptomatic HIV-Positive Patients When No CD4 Count Is Available? A Prospective Observational Cohort Study From Malawi. J Acquir Immune Defic Syndr. 2020 Jan 1;83(1):24-30. doi: 10.1097/QAI.0000000000002206. Erratum in: J Acquir Immune Defic Syndr. 2020 Apr 1;83(4):e28. PMID: 31633613; PMCID: PMC6903332.
Lee, S. -., Lin, C. -., Chuang, T. -., Huang, H. -., Kao, Y. -., & Wu, L. S. -. (2016). SNP rs4331426 in 18q11.2 is associated with susceptibility to tuberculosis among female han taiwanese. Journal of Microbiology, Immunology and Infection, 49(3), 436-438. doi:10.1016/j.jmii.2014.11.007.
Farr K, Ravindran R, Strnad L, Chang E, Chaisson LH, Yoon C, Worodria W, Andama A, Ayakaka I, Bbosa Nalwanga P, Byanyima P, Kalema N, Kaswabuli S, Katagira W, Aman KD, Musisi E, Tumwine NW, Sanyu I, Ssebunya R, Davis JL, Huang L, Khan IH, Cattamanchi A. Diagnostic performance of blood inflammatory markers for tuberculosis screening in people living with HIV. PLoS One. 2018 Oct 23;13(10):e0206119. doi: 10.1371/journal.pone.0206119. PMID: 30352099; PMCID: PMC6198956.
Downloads
Published
How to Cite
Issue
Section
License
The periodical offers access to content in the Open Access system under the Creative Commons Attribution-NonCommercial-ShareAlike 4.0
Stats
Number of views and downloads: 477
Number of citations: 0
