Prolonged intravenous infusion therapy of lidocaine in treatment of chronic venous insufficiency in C6 and C6R stage

Abstract

Chronic venous disease (CEAP stage C2 - C3) is found in approximately 25% of the population, and trophic skin changes, including leg ulcers (C4 - C6), up to 5%.

The aim of the work was to develop an effective dose and concentration of lidocaine and the optimal method of its administration for the treatment of chronic venous disease in the stage of active trophic wounds and accelerate the healing process.

Materials and methods. The results of treatment of 97 patients with chronic venous insufficiency in stage C6 and C6r were evaluated, which were divided into two clinical groups: retrospective (n= 50) in which classical surgical treatment was performed (Coquette veins ligation, Narat phlebectomy) and prospective (n=47) in which classical surgical intervention (crossectomy + Bebcock and / or Narat phlebectomy) was used in combination with the prolonged intravenous infusion therapy of lidocaine.

Research results and their discussion. In the period of 3-6 months, complete healing of trophic wounds was observed in the prospective group. At the same time, in 25.53% of patients in this group complete healing was observed up to 7 days. Whereas, in patients of the retrospective group, this was observed between 6-9 months. In addition, the rate of decrease in the area of trophic wound for the first month in the prospective group was 23.72% higher than in the retrospective group (р˂0.05). We did not observe a recurrence of a trophic wound in the follow-up period up to 1 year in the prospective group.