Wykorzystanie kozieradki pospolitej (Trigonella foenum-graecum L.) w zielarstwie i fitoterapii

Magdalena Kilar, Janusz Kilar

DOI: http://dx.doi.org/10.12775/HERB.2016.007


Kozieradka pospolita (Trigonella foenum-graecum L.) to zielna roślina jednoroczna. Su-rowcem zielarskim są nasiona kozieradki Semen Foenugraeci, które są bogatym źródłem substancji biologicznie czynnych, między innymi związków śluzowych, saponin steroido-wych, flawonoidów, steroli, witamin. Kozieradka pospolita wykazuje przede wszystkim działanie hipolidemiczne, przeciwhiperglikemiczne i hipoglikemiczne, neurologiczne, przeciwzapalne, przeciwdrobnoustrojowe, przeciwnowotworowe.

Słowa kluczowe

kozieradka; nasiona; fitoterapia; substancje biologicznie czynne

Pełny tekst:



Senderski M., Prawie wszystko o ziołach i ziołolecznictwie, Wyd. Podkowa Leśna, 2015, s. 356–358.

Xue W.L., Li X.S., Zhang J., Liu Y.H., Wang Z.L., Zhang R.J., Effect of Trigonella fo-enum-graecum fenugreek extracts on blood glucose, blood lipid and hemorheologi-cal properties in streptozotocin-induced diabetic rats, Asia Pacific Journal of Clinical Nutrition, 2007, 16 (1), s. 422–426.

Ożarowski A., Jaroniewski W., Rośliny lecznicze i ich praktyczne zastosowanie, Insty-tut Wydawniczy Związków Zawodowych, Warszawa, 1989, s. 207–208.

Rudkowska E., Smutkiewicz A., Han-Marek M., Zioła w terapii wspomagającej lecze-nie cukrzycy, Postępy Fitoterapii, 2006, 3, s. 155–162.

Król-Kogus B., Krauze-Baranowska M., Kozieradka pospolita Trigonella foenum gra-ecum L. – tradycja stosowania na tle wyników badań naukowych, Postępy Fitoterapii, 2011, 3, s. 185–190.

Krauze-Baranowska M., Król-Kogus B., Greckie siano, Boża trawka – Kozieradka, Pa-nacea, 2011, (4)37 X–XII, s. 20–21.

Lamer-Zarawska E., Kowal-Gierczak B., Niedworak I., Fitoterapia i leki roślinne. Wyd. Lekarskie PZWL, 2012.

Srichamroen A., Field C.J., Thomson A.B., Basu T.K., The Modifying Effects of Ga-lactomannan from Canadian-Grown Fenugreek Trigonella foenum-graecum L. on the Glycemic and Lipidemic Status in Rats, Journal of Clinical Biochemistry and Nutrition, 2008, 433, s. 167–174.

Brenac P, Sauvaire Y., Accumulation of sterols and steroidal sapogenins in developing fenugreek pods: Possible biosynthesis in situ, Phytochem, 1996, 41(2), s. 415–422.

Petit P., Sauvaire Y.D., Hillaire-Buys D.M. i wsp., Steroid saponins from fenugreek se-eds Extraction, purification, and pharmacological investigation on feeding behavior and plasma cholesterol, Steroids, 1995, 60(10), s. 674–80.

Prati S., Baravelli V., Fabbri D. i wsp., Composition and content of seed flavonoids in forage and grain legume crops, Journal of Separation Science, 2007, 30(4), s. 491–501.

Rayyan S., Fossen T., Andersen Q.M., Flavone CGlycosides from seeds of Fenugreek Trigonella foenum-graecum L., Journal of Agricultural and Food Chemistry, 2010, 58(12), s. 7211–7217.

Wang G., Tang W., Yao Q. i wsp., New flavonoids with 2BS cell proliferation pro-moting effect from the seeds of Trigonella foenum-graecum L., Journal of Natural Medicines, 2010, 64(3), s. 358–361.

Kochhar A., Nagi M., Sachdeva R., Proximate composition, available carbohydrates, dietary fibre and anti nutritional factors of selected traditional medicinal plants, Journal of Human Ecolpgy, 2006, 19, s. 195–199.

Han Y., Nishibe S., Noguchi Y. i wsp., Flavonol glycosides from the stems of Trigonella foenum-graecum, Phytochem, 2001, 58, s. 577–580.

Stadler R.H., Varga N., Hau J. i wsp., Alkylpyridinimus.1. Formation in model systems via thermal degradation of trigonelline, Journal of Agricultural and Food Chemistry, 2002, 50, s. 1192–1199.

Mebazaa R., Mahmoudi A., Fouchet M. i wsp., Characterization of volatile compo-unds in Tunisian fenugreek seeds, Food Chemistry, 2009, 115(4), s. 1326–1336.

Al-Habori M., Raman A., Antidiabetic and hypocholesterolaemic effects of fenugreek., Phytotherapy Research, 1998, 124, s. 233–242.

Saxena B., Saxena U., Anti-hyperlipidemic activity of fenugreek Trigonella foenum-graecum seeds extract in Triton and high fat diet induced hyperlipidemic model: A potent anti-antherosclerotic agent, Pharmacologyonline, 2009, 2, s. 616–624.

Vijayakumar M.V., Pandey V., Mishra G.C. i wsp., Hypolipidemic effect of fenugreek seeds is mediated through inhibition of fat accumulation and upregulation of LDL receptor, Obesity, 2010, 18(4), s. 667–674.

Nowak G. red., Leki pochodzenia naturalnego, Wyd. UM w Poznaniu, 2012.

Sharma R.D., Raghuram T.C., Rao N.S., Effect of fenugreek seeds on blood glucose and serum lipids in type I diabetes, European Journal of Clinical Nutrition, 1990, 44(4), s. 301–306.

Yamada T., Hoshino M., Hayakawa T. Ohhara H. Yamada H. Nakazawa T., Dietary diosgenin attanuates subacute intestinal inflammation associated with indomethacin in rats, American Journal of Physiology, 1997, 273 (2/1), s. 355–364.

Boban P.T., Nambisan B., Sudhakaran P.R., Hypolipidaemic effect of chemically diffe-rent mucilages in rats: A comparative study, British Journal of Nutrition, 2006, 96(6), s. 1021–1029.

Sauvaire Y., Ribes G., Baccou J. i wsp., Implication of steroid saponins and sapogenin in the hypocholesterolemic effect of fenugreek, Lipids, 1991, 26(3), s. 191–197.

Francis G., Kerem Z., Makkar I. i wsp., The biological action of saponins in animal systems: A review, British Journal of Nutrition, 2002, 88(6), s. 587–605.

Kamanna V.S., Kashyap M.L., Mechanism of action of niacin, American Journal of Cardiology, 2008, s. 101.

Neelakantan N., Narayanan M., de Souza R.J., van Dam R.M., Effect of fenugreek Trigonella foenum-graecum L. intake on glycemia: a meta-analysis of clinical trials, Nutrition Journal, 2014, 13, s. 7.

Kania M., Derebecka N., Surowce roślinne w cukrzycy typu 2, Postępy Fitoterapii, 2010, 2, s. 76–84.

Mohammad S., Taha A., Akhtar K. i wsp., In vivo effect of Trigonella foenum gra-ecum on the expression of pyruvate kinase, phosphoenolpyruvate carboxykinase, and distribution of glucose transporter GLUT4 in alloxan-diabetic rats., Canadian Jour-nal of Physiology and Pharmacology, 2006, 84(6), s. 647–654.

Mowla A., Alauddin M., Rahman M.A., Ahmed K., Antihyperglycemic effect of Tri-gonella foenum-graecum Fenugreek seed extract in alloxan-induced diabetic rats and its use in diabetes mellitus: a brief qualitative phytochemical and acute toxicity test on the extract, African Journal Traditional Complementary and Alternative Medicines, 2009, 63, s. 255–261.

Suresh Kumar G., Shetty A.K., Salimath P.V., Modulatory effect of fenugreek seed mucilage and spent turmeric on intestinal and renal disaccharidases in streptozotocin induced diabetic rats, Plant Foods for Human Nutrition, 2005, 60(2), s. 87–91.

Haeri M.R., Izaddoost M., Ardekani M.R..S i wsp., The effect of fenugreek 4-hy-droxyisoleucine on liver function biomarkers and glucose in diabetic and fructose-fed rats, Phytotherapy Research, 2009, 23(1), s. 61–64.

Arshadi S., Azarbayjani M.A., Hajaghaalipor F., Yusof A., Peeri M., Bakhtiyari S., Stan-nard R.S., Osman N.A., Dehghan F. Evaluation of Trigonella foenum-graecum extract in combination with swimming exercise compared to glibenclamide consumption on type 2 Diabetic rodents, Food and Nutrition Research, 2015, 59, s. 29717.

Lu F., Shen L., Qin Y. i wsp., Clinical observation of Trigonella foenum-graecum sapo-nin combining sulphanylureas on 36 cases of type 2 diabetes mellitus, China Journal of Chinese Materia Medica, 2008, 33(2), s. 184–187.

Kannappan S., Anuradha.CV., Insulin sensitizing actions of fenugreek seed polyphe-nols, quercetin and metformin in a rat model, Indian Journal of Medical Research, 2009, 129(4), s. 401–408.

Kumar Gupta S., Kalaiselvan V., Srivastava S., Saxena R., Sunder Agrawal S., Inhibi-tory Effect of Trigonella Foenum-Graecum on Galactose Induced Cataracts in a Rat Model; in vitro and in vivo Studies, Journal of Ophthalmic and Vision Research, 2009, 4(4), s. 213–219.

Tohda C., Kuboyama T., Komatsu K., Search for natural products related to regenera-tion of the neuronal network, Neuro Signals, 2005, 14, s. 34–45.

Tohda C., Nakamura N., Komatsu.K i wsp., Trigonellinae-induced neurite outgrowth in human neuroblastoma SK-N-SH cells, Biological and Pharmacetical Bulletin, 1999, 22(7), s. 679–682.

Nathan J., Panjwani S., Mohan V., Joshi V., Thakurdesai P.A., Efficacy and Safety of Standardized Extract of Trigonella foenum-graceum L. Seeds as an Adjuvant to L-Dopa in the Management of Patients with Parkinson’s Disease, Phytother Research. 2014, 28(2), s. 172–178.

Malviya Kapil G., Babhulkar Mukesh W., Mali Prashant.Y i wsp., Evaluation of anti-in-flammatory potential of Trigonella foenum-graecum fenugreek seed extracts by using carrageenan induced rat paw edema, Drug Invention Today, 2010, 2(2), s. 109–111.

Pandey H., Awasthi P., Effect of processing techniques on nutritional composition and antioxidant activity of fenugreek Trigonella foenum-graecum seed flour, Journal of Food Science and Technology, 2015, 52(2), s. 1054–1060.

Vyas S., Prasad Agrawal R., Solanki P., Trivedi P., Analgesic and anti-inflammatory activities of Trigonella foenum-graecum seed extract, Acta Poloniae Pharmaceutica Drug Research, 2008, 65, 4, s. 473–476.

Wagh P., Rai M., Deshmukh S.K. i wsp., Bioactivity of oils of Trigonella foenum-graecum and Pongamia pinnata, African Journal of Biotechnology, 2007, 6(13), s. 1592–1596.

Haouala R., Hawala S., El-Ayeb.A i wsp., Aqueous and organic extracts of Trigonella foenumgraecum L. inhibit the mycelia growth of fungi, Journal of Environmental Sciences, 2008, 20(12), s. 1453–1457.

Olli S., Kirti P.B., Characterization and Antifungal Activity of Defensin Tfgd1 from Trigonella foenum-graecum L., Journal of Biochemistry and Molecular Biology, 2006, 39, 3, s. 278–283.

Alsemari A., Alkhodairy F., Aldakan A., Al-Mohanna M., Bahoush E., Shinwari Z., Alaiya A., The selective cytotoxic anti-cancer properties and proteomic analysis of Trigonella Fo-enum-Graecum, BMC Complementary and Alternative Medicine, 2014, 14, s. 114.

Goyal S., Gupta N., Chatterjee S., Investigating Therapeutic Potential of Trigonella foenum-graecum L. as Our Defense Mechanism against Several Human Diseases, Hindawi Publishing Corporation Journal of Toxicology. 2016, Volume 2016, Article ID 1250387, 10 pages, http://dx.doi.org/10.1155/2016/1250387.

Eisenhardt S., Schwarzmann N., Henschel V., Germeyer A., Von Wolf M., Hamann A., Strowitzki T., Early effects of Metformin in women with polycystic ovary syndrome: A prospective randomized, double-blind, placebo-controlled trial, Journal of Clinical Endocrinology and Metabolism, 2006, 91, s. 946–952.

Khoja K.K., Shaf G., Hasan T.N., Syed N.A., Al-Khalifa A.S., Al-Assaf A.H., Alshatwi A.A., Fenugreek, a naturally occurring edible spice, kills MCF-7 human breast can-cer cells via an apoptotic pathway, Asian Pacific Journal of Cancer Prevention, 2011, 12(12), s. 3299–3304.

Li F., Fernandez P.P., Rajendran P. i wsp., Diosgenin, a steroidal saponin, inhibits STAT3 signaling pathway leading to suppression of proliferation and chemosensitiza-tion of human hepatocellular carcinoma cells, Cancer Letters, 2010, 292, s. 197–207.

Hakimi S., Mohammad Alizadeh S., Delazar A. Abbasalizadeh F., Bam-dad Mogad-dam R., Siiahi M.R., Mostafa Garabagi P. Probable effects of fenugreek seed on hot flash in menopausal women, Journal of Medicinal Plants Research, 2006, 5, s. 9–14.

Hassanzadeh Bashtian M., Emami S. A., Mousavifar N., Esmaily H. A., Mahmoudi M., Mohammad Poor A. H., Evaluation of Fenugreek Trigonella foenum-graceum L., Effects Seeds Extract on Insulin Resistance in Women with Polycystic Ovarian Syn-drome, Iranian Journal of Pharmaceutical Research, 2013, 12(2), s. 475–481.

Swaroop A., Jaipuriar A.S., Gupta S.K., Bagchi M., Kumar P., Preuss H.G., Bagchi D., Efficacy of a Novel Fenugreek Seed Extract Trigonella foenum-graecum, Furocy-stTM in Polycystic Ovary Syndrome PCOS, International Journal of Medical Sciences, 2015, 12(10), s. 825–831.

Kassem, A., Al-Aghbari, A., Al-Habori M., Al-Mamary, M., Evalu-ation of the poten-tial antifertility effect of fenugreek seeds in male and female rabbits. Contraception, 2006, 73, s. 301–306.

Jiang J.X., Zhu L.W., Zhang W.M., Sun R.C., Characterization of ga-lactomannan gum from fenugreek Trigonella foenum-graecum se-eds and its rheological properties, In-ternational Journal of Polymeric Materials, 2007, 56(12), s. 1145–1154.

Sangeetha R., Activity of Superoxide Dismutase and Catalase in Fenugreek Trigonel-la foenum-graecum in Response to Carbendazim, Indian Journal of Pharmaceutical Sciences, 2010, https://www.researchgate.net/publication/44803966.

Suja Pandian R., Anuradha C.V., Viswa Neelakantan an P., Gastroprotective effect of fenugreek seeds Trigonella foenum graecum on experimental gastric ulcer in rats, Journal of Ethnopharmacology, 2002, 81(3), s. 393–397.

Langmead L., Dawson C., Hawkins.C i wsp., Antioxidant effects of herbal therapies used by patients with inflammatory bowel disease: an in vitro study, Alimentary Pharmacology and Therapeutics, 2002, 16, s. 197–205.

Mahmood A.A., Sidik K., Salmah I., Anti-ulcer and gastro protective effects of honey in combination with Trigonella foenum-graecum seed extract on experimental ga- stric ulcer in rats, International Journal of Molecular Medicine and Advance Sciences, 2005, 1(3), s. 225–229.

Pribac G., Ardelean A., Czapar M. i wsp., Trigonella foenum-graecum and Trigonella policreata seeds extract exert a protective action of alcohol toxicity in BRL3A rat liver cells, Studia Univ, Ser ŞV, 2009, 19, s. 87–93.

Kaviarasan S., Ramamurty N., Gunasekaran P., Varalakshmi E., Anuradha C.V., Fe-nugreek Trigonella foenum graecum seed extract prevents ethanol-induced toxicity and apoptosis in Chang liver cells, Alcohol and Alcoholism, 2008, 41(3), s. 267–273.

Kaviarasan S., Anuradha C.V., Fenugreek Trigonella foenum graecum seed polyphe-nols protect liver from alcohol toxicity: A role on hepatic detoxification system and apoptosis, Pharmazie, 2007, 62(4), s. 299–304.

Khader M., Eckl P.M., Bresgen N., Effects of aqueous extracts of medicinal plants on MNNG-treated rat hepatocytes in primary cultures, Journal of Ethnopharmacology, 2007, 112(1), s. 199–202.

Pyrzanowska J., Piechal A., Blecharz-Klin K., Widy-Tyszkiewicz E., Interakcje leków roślinnych stosowanych w chorobach układu pokarmowego, Herba Polonica, 2006, 52(1/2), s. 75–96.

Abebe W., Herbal medication: potential for adverse interactions with analgesic drugs, Journal of Clinical Pharmacy and Therapeutics, 2002, 27(6), s. 391–401.

Lambert J.P., Cormier A., Potential interaction between warfarin and boldo-fenugre-ek, Pharmacotherapy, 2001, 21(4), s. 509–512.

Hylek E..M, Heiman H., Skates S.J., Sheehan M.A., Singer D.E., Acetaminophen and other risk factors for excessive warfarin anticoagulation, JAMA, 1998, 279(9), s. 657–662.

Srinivasan K., Plant foods in the management of diabetes mellitus: spices as benefi-cial antidiabetic food adjuncts, International Journal of Food Sciences and Nutrition, 2005, 56(6), s. 399–414.

Tahiliani P., Kar A., The combined effect of Trigonella and Allium extracts in the regu-lation of hyperthyroidism in rats, Phytomedicine, 2003, 10(8), s. 665–668.

Benayad Z., Gómez-Cordovés C., Es-Safi N.E., Characterization of Flavonoid Glycosi-des from Fenugreek Trigonella foenum-graecum Crude, Seeds by HPLC–DAD–ESI/MS Analysis, International Journal of Molecular Sciences, 2014, 15, s. 20668–20685.

Krauze-Baranowska M., Arnica, karczoch i Kozieradka w laboratorium, Panacea, 2004, 27, s. 32.

Miraldi E., Ferri S., Mostaghimi V., Botanical drugs and preparations in the traditional me-dicine of West Azerbaijan Iran, Journal of Ethnopharmacology, 2001, 75(2–3), s. 77–87.

Bellakhdar J., La Pharmacopée Marocaine Traditionnelle, Médecine Arabe Ancienne et Savoirs Populaires, Ibis Press, Paris, France, 1997, s. 764.

Petit P., Sauvaire Y., Ponsin G., Manteghetti M., Fave A., Ribes G., Effect of a fenugre-ek seed extraction on feeding behaviour in the rat: Metabolic-endocrine correlates, Pharmacology Biochemistry and Behavior, 1993, 45, s. 369–374.

Ravikumar P., Anuradha C.V., Effect of fenugreek seeds on blood lipid peroxidation and antioxidants in diabetic rats, Phytotherapy Research, 1999, 13, 3, s. 197–201.

Sauvaire Y., et al., 4-Hydroxyisoleucine: a novel amino acid potentiator of insulin se-cretion, Diabetes, 1998, 47, 2, s. 206–210.

Mishkinsky J.S., et al., Hypoglycaemic effect of Trigonella foenum graecum and Lupi-nus termis leguminosae seeds and their major alkaloids in alloxan-diabetic and normal rats, Archives Internationales de Pharmacodynamie et de Thérapie, 1974, 210, 1, s. 27–37.

Satheeshkumar N., et al., Acetylcholinesterase enzyme inhibitory potential of stan-dardized extract of Trigonella foenum graecum L and its constituents, Phytomedicine, 2010, 17, 3, s. 292–295.

Bodor N., Buchwald P., Barriers to remember: brain-targeting chemical delivery sys-tems and Alzheimer’s disease, Drug Discovery Today, 2002, 7,14, s. 766–774.

Toshiaki H., et al., Effects of fenugreek seed extract in obese mice fed a high-fat diet, Bioscience Biotechnology and Biochemistry, 2005, 69,6, s.1186–1188.

Nanal V.R.M., Food In Pregnancy An Ayurvedic Overview, Ancient Science of Life, 2008, 28, 1, s. 30.

Posadzki P., Leala W., Edzard E., Herb–drug interactions: an overview of systematic reviews, British Journal of Clinical Pharmacology, 2013, 75, 3, s. 603–618.

Yarnell E., Kathy A., Overview of drug-herb interactions, Alternative and Comple-mentary Therapies, 2002, 8, 2, s. 87–96.

Araee M. et al, Toxicity of Trigonella foenum graecum fenugreek in bone marrow cell proliferation in rat, Pakistan Journal of Pharmaceutical Sciences, 2009, 22, 2, s. 126–130.

Ghulam J., Su H.C.F., Laboratory studies on several plant materials as insect repellants for protection of cereal grains, Journal of Economic Entomology, 1983, 76,1, s. 154–157.


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