TY - JOUR AU - Bombushkar, Igor AU - Gozhenko, Anatoliy AU - Korda, Mykhaylo AU - Żukow, Xawery AU - Popovych, Igor PY - 2022/10/31 Y2 - 2024/03/29 TI - Peculiarities of relationships between plasma levels of nitrogenous metabolites and EEG & HRV parameters in patients with postradiation encephalopaty JF - Journal of Education, Health and Sport JA - J Educ Health Sport VL - 12 IS - 10 SE - Articles DO - 10.12775/JEHS.2022.12.10.040 UR - https://apcz.umk.pl/JEHS/article/view/40720 SP - 335-355 AB - <p><strong>Background</strong>.&nbsp;Recently we shown that nitrogenous&nbsp;plasma&nbsp;metabolites (uric acid, bilirubin, urea and creatinine), even&nbsp;in&nbsp;the&nbsp;absence&nbsp;of&nbsp;uremia, are&nbsp;able&nbsp;to&nbsp;influence&nbsp;the&nbsp;state&nbsp;of&nbsp;the&nbsp;anxiety, autonomic&nbsp;and&nbsp;central&nbsp;nervous&nbsp;and&nbsp;endocrine&nbsp;systems, apparently&nbsp;through&nbsp;aryl&nbsp;hydrocarbon&nbsp;and&nbsp;adenosine&nbsp;receptors&nbsp;of&nbsp;neurons&nbsp;and&nbsp;endocrine cells&nbsp;and/or&nbsp;directly.&nbsp;Sexual dimorphism in the neurotropic effects of uric acid in neurologically healthy patients was also revealed.&nbsp;The purpose of this study is to compare nitrogenous-neural relationships in neurologically healthy men and those with post-radiation encephalopathy (PREP).&nbsp;<strong>Materials</strong><strong>&nbsp;</strong><strong>and</strong><strong>&nbsp;</strong><strong>Methods</strong>.&nbsp;The object of observation were neurologically&nbsp;healthy 31 men (24÷69 y)&nbsp;and 19 patients (26÷61 y) with PREP. The relationships between plasma levels of nitrogenous metabolites, on the one hand, and EEG and HRV&nbsp;parameters, on the other, were analyzed.&nbsp;<strong>Results</strong>. By constructing regression models with stepwise elimination it was found that the multiple correlation coefficient (R±µ) of creatinine with neural parameters in patients with PREP significantly exceeded that of control patients (0,762±0,069 vs 0,409±0,107; t=2,62; p=0,011).&nbsp;With regard to urea, the differences are insignificant&nbsp;(0,801±0,059 vs 0,694±0,066; t=1,17; p&gt;0,2), and with regard to bilirubin (0,548±0,115&nbsp;vs 0,402±0,107; t=0,94) and uric acid (0,496±0,124 vs 0,549±0,089; t=0,32), there are practically no differences. <strong>Conclusion</strong><strong>. </strong>Post-radiation&nbsp;encephalopathy&nbsp;is&nbsp;accompanied&nbsp;not&nbsp;only&nbsp;by&nbsp;deviations&nbsp;from&nbsp;the&nbsp;norm&nbsp;of&nbsp;a&nbsp;number&nbsp;of&nbsp;EEG&nbsp;and&nbsp;HRV&nbsp;parameters, but&nbsp;also&nbsp;by&nbsp;their&nbsp;increased&nbsp;sensitivity&nbsp;to&nbsp;creatinine&nbsp;and, to a lesser extent,&nbsp;urea, but&nbsp;not&nbsp;to&nbsp;bilirubin&nbsp;and&nbsp;uric&nbsp;acid.</p> ER -