TY - JOUR AU - Badiuk, Nataliya AU - Popovych, Dariya AU - Hrytsak, Myroslava AU - Ruzhylo, Sofiya AU - Zakalyak, Nataliya AU - Kovalchuk, Galyna AU - Mel’nyk, Oksana AU - Zukow, Xawery PY - 2021/11/30 Y2 - 2024/03/28 TI - Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats JF - Journal of Education, Health and Sport JA - J Educ Health Sport VL - 11 IS - 11 SE - Research Articles DO - 10.12775/JEHS.2021.11.11.031 UR - https://apcz.umk.pl/JEHS/article/view/37541 SP - 314-333 AB - <p><strong>Background.</strong>&nbsp;Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’&nbsp;spa&nbsp;has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems.&nbsp;In this study, conducted in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum, data on the immunomodulatory effects of these waters on the same rats.&nbsp;<strong>Materials and Methods</strong>. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna".&nbsp;The object of the study were the immune parameters of the thymus, spleen and blood.&nbsp;<strong>Results</strong>. The method of discriminant analysis revealed 12 parameters, according to which the animals loaded with mineral waters differed significantly from both control and intact animals.&nbsp;Classification accuracy is 86%. However, the&nbsp;difference&nbsp;between&nbsp;the&nbsp;immunotropic&nbsp;effects&nbsp;of&nbsp;mineral&nbsp;waters&nbsp;of&nbsp;different&nbsp;mineralization&nbsp;concerns&nbsp;only&nbsp;9 parameters.<strong>&nbsp;Conclusion</strong>. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’&nbsp;spa&nbsp;have both similar and specific&nbsp;immunomodulating&nbsp;effects on healthy old female rats with weekly use.&nbsp;This provides a basis for preclinical studies.</p> ER -