TY - JOUR AU - Kuchma, Igor AU - Gozhenko, Anatoliy AU - Flyunt, Igor-Severyn AU - Ruzhylo, Sofiya AU - Nahurna, Yaryna AU - Zukow, Walery AU - Popovych, Igor PY - 2021/02/28 Y2 - 2024/03/28 TI - Role of the autonomic nervous system and lipoperoxidation in immunotropic effects of nitrogenous metabolites in patients with postradiation encephalopathia JF - Journal of Education, Health and Sport JA - J Educ Health Sport VL - 11 IS - 2 SE - Research Articles DO - 10.12775/JEHS.2021.11.02.015 UR - https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.02.015 SP - 145-155 AB - <p class="MsoNormal"><strong><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background.</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> We have previously shown that nitrogenous metabolites</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">have immunomodulatory effects, both suppressor and enhancing,</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL- and </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">a</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">denosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">A strong correlation was found</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">between the constellation of nitrogenous metabolites, on the one hand, and the HRV markers of ANS, on the other hand. The </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">aim</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> of this study is to analyze the relationships between HRV markers of the parameters of the ANS as well as Lipoperoxidation, on the one hand, and the parameters of Immunity - on the other hand. </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Material and methods</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Ch</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">о</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">rnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice - on admission and after two weeks of rehabilitation at the Truskavets’ Spa</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">. </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">The</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">state</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">of</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">the</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">autonomic</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">nervous</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">system</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">(ANS) </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">was</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">judged</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">by</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">the</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">HRV</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">parameters</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">recorded</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">before</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">and</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">after</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">submaximal</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">bicycle</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">ergometric</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">loading</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;">.</span><span class="16" style="font-family: 'Times New Roman'; color: #222222; background-image: initial; background-position: initial; background-size: initial; background-repeat: initial; background-attachment: initial; background-origin: initial; background-clip: initial;"> The state of lipid peroxidation assessed the content in the serum diene conjugates, malonic dyaldehid, activity of catalase serum and superoxide dismutase erythrocytes.</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; font-size: 12,0000pt;"> </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Results</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">.</span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';"> The coefficient of canonical correlation between the constellation of HRV markers of ANS and parameters of Immunity was 0</span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">,947 (χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(126)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=178; p=0,002) The inclusion in factor structure parameters of </span><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">Lipoperoxidation increases </span><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R to 0,973 (χ</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(231)</span></sub><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=314; p&lt;10</span><sup><span style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-6</span></sup><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">). </span><strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman'; mso-ansi-font-weight: bold;">Conclusion</span></strong><span class="15" style="mso-spacerun: 'yes'; font-family: 'Times New Roman';">. Previously identified immunomodulatory effects of urea and creatinine as well as uric acid and bilirubin are realized, possibly, through cholinergic and adrenergic mechanisms as well as reactive oxygen species.</span></p> ER -