TY - JOUR AU - Sorokman, Tаmila AU - Chernei, Nadiia AU - Sokolnyk, Snizhana AU - Sokolnyk, Iryna AU - Popelyuk, Nataliya PY - 2020/11/30 Y2 - 2024/03/29 TI - The influence of Helicobacter pylori on the level of endotheline-1 and nitrogen oxide in the blood of children with the duodenal ulcer JF - Journal of Education, Health and Sport JA - J Educ Health Sport VL - 10 IS - 11 SE - Research Articles DO - 10.12775/JEHS.2020.10.11.026 UR - https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.11.026 SP - 261-272 AB - <p>The most serious pathology of the of gastrointestinal tract in children remains duodenal ulcer (DU). Interesting is the study of the role of endothelin-1 and nitrogen oxide in the formation of DU.</p><p>The aim. To evaluate the nature of changes in the level of nitrogen oxide (NO) and endothelin-1 (Et-1) in the blood of children with H pylori-associated DU.</p><p>Methods. A single-center study was conducted in 42 children with DU aged 6–18 years and 20 children comparison group. Diagnostics of H. pylori was performed primary endoscopy and 4 weeks after the end of treatment. Blood samples were collected in each visit to measure plasma Et-1 using an enzyme immunoassay kit and NO (nitrate/nitrite) levels Golikov's method.</p><p>Results. In 37 (92.5%) the ulcers went through re-epithelialization, while successful eradication of H. pylori was achieved in 32 people (80%). The NO level in the blood plasma of the children of the main group was 9.78 ± 1.13 mmol/l, after treatment –11.09 ± 1.2 mmol/l. After eradication of H. pylori, the level of Et-1 decreased from 2.39 ± 0.08 to 1.14 ± 0.07 pg / ml.</p><p>Conclusion. Levels of endothelin-1 (Et-1) and nitrogen oxide (NO) in children with duodenal ulcer vary depending on the stage of the disease. After H-pylori eradication, ulcer defect healing is associated with decreased of Et-1 inplasma and increased NO activity.</p> ER -