TY - JOUR AU - Konopelko, Michał AU - Nieradko-Iwanicka, Barbara PY - 2020/08/06 Y2 - 2024/03/28 TI - Effect of subacute poisoning with selected pyrethroids on fresh spatial memory and movement activity in mice JF - Journal of Education, Health and Sport JA - J Educ Health Sport VL - 10 IS - 8 SE - Research Articles DO - 10.12775/JEHS.2020.10.08.015 UR - https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.08.015 SP - 132-137 AB - <p>Introduction. Pyrethroids are commonly used in agriculture and for indoor insect control. They act as neurotoxins mainly  <em>via</em> sodium channels in neurons. People can be exposed to traces of these xenobiotics dermally, with food, at home or at workplace. Three pyrethroids: cypermethrin, lambdacyhalothrin, and betacyfluthrin were chosen for modelling subacute oral poisoning in mice.</p><p align="left">The aim of the study was to assess if 7-day exposure to 0.1LD<sub>50</sub> of each compound could impair memory and motor activity in mice.</p><p>Material and methods. A total of 64 mice were divided into  8 groups of 8 animals: females controls, males controls, females receiving cypermethrin, males receiving cypermethrin, females receiving lambdacyhalothrin, males receiving lambdacyhalothrin, females receiving  betacyfluthrin, males receiving betacyfluthrin. They were given 0.1LD<sub>50</sub> of a pyrethroid dissolved in canola oil by gavage daily for 7 days. They were tested in a Y-maze on day 1 and 7.</p><p>Results. Subacute poisoning with betacyfluthrin significantly reduces locomotor activity in females on day 1  and in both genders on day 7 without effect on fresh spatial memory.</p><p>Conclusion. Betacyfluthrin is the most harmful of the tested pesticides.</p> ER -