@article{Badiuk_Popovych_Hrytsak_Ruzhylo_Zakalyak_Kovalchuk_Mel’nyk_Zukow_2021, title={Similar and specific immunotropic effects of sulfate-chloride sodium-magnesium mineral waters "Myroslava" and "Khrystyna" of Truskavets’ spa in healthy female rats}, volume={11}, url={https://apcz.umk.pl/JEHS/article/view/37541}, DOI={10.12775/JEHS.2021.11.11.031}, abstractNote={<p><strong>Background.</strong> Earlier in an experiment on rats, we showed that newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa has a significant modulating effect on the parameters of metabolism and the autonomic nervous and endocrine systems. In this study, conducted in line with the concepts of neuroendocrine-immune complex and functional-metabolic continuum, data on the immunomodulatory effects of these waters on the same rats. <strong>Materials and Methods</strong>. Experiment was performed on 50 healthy female Wistar rats 230-290 g divided into 4 groups. Animals of the first group remained intact, using tap water from drinking ad libitum. Rats of the second (control) group for 6 days administered a single tap water through the tube at a dose of 1,5 mL/100 g of body mass. The rats of the main groups received the water "Myroslava" and "Khrystyna". The object of the study were the immune parameters of the thymus, spleen and blood. <strong>Results</strong>. The method of discriminant analysis revealed 12 parameters, according to which the animals loaded with mineral waters differed significantly from both control and intact animals. Classification accuracy is 86%. However, the difference between the immunotropic effects of mineral waters of different mineralization concerns only 9 parameters.<strong> Conclusion</strong>. The newly created sulfate-chloride sodium-magnesium drinking mineral waters of Truskavets’ spa have both similar and specific immunomodulating effects on healthy old female rats with weekly use. This provides a basis for preclinical studies.</p>}, number={11}, journal={Journal of Education, Health and Sport}, author={Badiuk, Nataliya and Popovych, Dariya and Hrytsak, Myroslava and Ruzhylo, Sofiya and Zakalyak, Nataliya and Kovalchuk, Galyna and Mel’nyk, Oksana and Zukow, Xawery}, year={2021}, month={Nov.}, pages={314–333} }