@article{Kuchma_Gozhenko_Bilas_Huchko_Ponomarenko_Nahurna_Zukow_Popovych_2021, title={Relationships between parameters of nitrogenous metabolites and HRV in humans exposed to the factors of the accident at the Chоrnobyl Nuclear Power Plant}, volume={11}, url={https://apcz.umk.pl/JEHS/article/view/JEHS.2021.11.01.025}, DOI={10.12775/JEHS.2021.11.01.025}, abstractNote={<p class="MsoNormal"><strong><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-ansi-font-weight: bold; font-size: 12,0000pt;">Background.</span></strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> We have previously shown that nitrogenous metabolites</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">have immunomodulatory effects, both suppressor and enhancing,</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">both in healthy rats and in humans exposed to pathogenic influences. The immunomodulatory effect of bilirubin is probably mediated through aryl hydrocarbon receptors, and uric acid through TL- and </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">a</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">denosine receptors of immune cells. The question of mediators of the immunomodulatory action of urea and creatinine remains open. We hypothesized the mediating role of mediators of the autonomic nervous system and adaptation hormones.</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">The </span><strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-ansi-font-weight: bold;">aim</span></strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> of this study is to analyze the relationships between the parameters of nitrogenous metabolites, on the one hand, and HRV markers of the parameters of the autonomic nervous system - on the other hand. </span><strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-ansi-font-weight: bold;">Material and methods</span></strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">. The object of observation in 1997 were 19 men and 3 women who were exposed to pathogenic factors of the accident at the Ch</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">о</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">rnobyl nuclear power plant during the liquidation of its consequences in 1986-87. The survey was conducted twice - on admission and after two weeks of rehabilitation at the Truskavets’ Spa</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;">. </span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;">The plasma and urinary concentration of the nitrogenous metabolites were determined</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;">. </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">The</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">state</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">of</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">the</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">autonomic</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">nervous</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">system</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">(ANS) </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">was</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">judged</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">by</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">the</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">HRV</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">parameters</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">recorded</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">before</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">and</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">after</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">submaximal</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">bicycle</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">ergometric</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">loading</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;">. </span><strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-ansi-font-weight: bold;">Results</span></strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">. </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">Both negative and positive metabolic-</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">ANS</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> correlations were revealed.</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">Calculation of multiple correlation coefficients between individual metabolite parameters and constellations of HRV parameters revealed the maximum vegetotropic effect of Urea</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">plasma</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> (R=0,700)</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> and Uric acid </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">urine</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> (R=0,623).</span><span class="15" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">This is followed by Urea</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;"> urine (R=0,531) and </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">Creatinine plasma (R=0,457). No significant correlations were found for </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">C</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">reatinine</span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; font-size: 12,0000pt;"> urine, </span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">Uric acid plasma and Bilirubinemia. The canonical correlation between the constellation of nitrogenous metabolites, on the one hand, and the HRV markers of ANS, on the other hand, was strong</span><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">: </span><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-bidi-font-weight: bold; font-size: 12,0000pt;">R=0,747; χ</span><sup><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">2</span></sup><sub><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: sub;">(28)</span></sub><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-bidi-font-weight: bold; font-size: 12,0000pt;">=63; p<10</span><sup><span style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-bidi-font-weight: bold; font-size: 12,0000pt; vertical-align: super;">-3</span></sup><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">. </span><strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’; mso-ansi-font-weight: bold;">Conclusion</span></strong><span class="16" style="mso-spacerun: ’yes’; font-family: ’Times New Roman’;">. Previously identified immunomodulatory effects of urea and creatinine are realized, possibly through cholinergic and adrenergic mechanisms.</span></p>}, number={1}, journal={Journal of Education, Health and Sport}, author={Kuchma, Igor and Gozhenko, Anatoliy and Bilas, Volodymyra and Huchko, Bohdan and Ponomarenko, Ruslan and Nahurna, Yaryna and Zukow, Walery and Popovych, Igor}, year={2021}, month={Jan.}, pages={253–268} }