@article{Zarankiewicz_Kosz_Kuchnicka_Zielińska_Wolanin_Ciseł_2020, title={Endometriosis and ovarian cancer - what they have in common?}, volume={10}, url={https://apcz.umk.pl/JEHS/article/view/JEHS.2020.10.08.026}, DOI={10.12775/JEHS.2020.10.08.026}, abstractNote={<p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><strong>Introduction and purpose: </strong></span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">Endometriosis is one of the most common diseases among women in the reproductive age. Although its etiology remains not fully understood, several models of endometriosis development are taken into consideration. Many studies have been focused on hormonal and genetic alterations in endometriosis. The results of these studies allow for a thesis on common origin of endometriosis and</span></span><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">a few types of ovarian cancer. </span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">The aim of this review is to present actual knowledge about endometriosis’ development conditions and a possible association with ovarian cancer.</span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><strong>Material and method: </strong></span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">The review concerned articles published in years 2012-2020, which were collected in the PubMed and Google Scholar. Particular attention was paid to the development of both the endometriosis and Endometriosis-Related Ovarian Neoplasms (ERONs) and their genetic disorders.</span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><strong>Results:</strong></span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">Endometriosis development is connected with several risk factors and also immune, hormonal and genetic alterations. Some authors postulated that malignant transformation of endometriosis may be a multi-step process powered by increasing levels of estrogen. Many studies confirmed that mutations of </span></span><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><em>ARID1A</em></span></span><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"> and </span></span><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><em>PIK3CA </em></span></span><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">genes are likely to be present in the majority of cases of ovarian cancer with adjacent endometriosis.</span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;"><strong>Conclusions:</strong></span></span></p><p class="western" align="justify"><span style="font-family: ’Times New Roman’, serif;"><span style="font-size: medium;">The awareness of clinical features and medical complications of endometriosis is spreading increasingly around the world. Many studies are focused on genetic causes of this illness. It may be supposed that we will be able to select women with endometriosis and increased risk of ovarian cancer and prevent its development.</span></span></p>}, number={8}, journal={Journal of Education, Health and Sport}, author={Zarankiewicz, Natalia and Kosz, Katarzyna and Kuchnicka, Aleksandra and Zielińska, Martyna and Wolanin, Natalia and Ciseł, Bogumiła}, year={2020}, month={Aug.}, pages={230–239} }