Safety study of extract of medicago sativa sowing grass
DOI:
https://doi.org/10.12775/PPS.2015.01.02.002Keywords
safety, an extract from the herb alfalfa seed, acute toxicity, LD50 dose, morphological structure of tissues.Abstract
In this study there was determined the absence of toxic effect after a single intragastric administration of EGMS at a dose of 5000 mg / kg to male and female rats. According to the conventional toxicological classification of substances, under the intragastric administration EGMS belongs to class V of toxicity – practically harmless substances (LD50 >5000 mg / kg). The results of macro- and microscopic studies of internal organs in 14 days after a single intragastric administration of EGMS at a dose of 5000 mg / kg showed the absence of any anatomical and morphological disorders in tissue structures of male and female rats. The calculated value of TI, which lies beyond 200, indicates a high level of safety of EGMS and its prospectivity for medical practice as an effective and safe corrector of protein metabolism with an anabolic action.
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