Positive Effect of Generation of Reactive Oxygen Species on the Human Organism
DOI:
https://doi.org/10.12775/mbs-2013-0011Keywords
reactive oxygen species, oxidant-antioxidant balance, human physiologyAbstract
For aerobes including human, the oxygen is an indispensable element for life, but simultaneously at too high concentration this gas becomes toxic. On the physiological level, the appropriate concentration of oxygen which is the source of reactive oxygen species (ROS), is necessary for the proper functioning of the organism. O2 and its derivatives as free radicals influence the maintenance of homeostasis of the human organism by acting at a cellular level on repair, protective, and energetic mechanisms, and at an intercellular level on communication between neighbouring cells and tissues. In turn, excess or impaired removal of ROS lead to so-called ‘oxidative stress’ that is associated with the pathogenesis of many diseases - from cancers to neurodegenerative, autoimmune and infectious diseases. In the paper the significance of only physiological level of reactive oxygen species in the human organism was presented.References
Bartosz G.: Druga twarz tlenu. PWN, Warszawa, 2009.
Bobrowski K. Free radicals in chemistry, biology and medicine: contribution of radiation chemistry. Nukleonika 2005; 50(3): 67-76.
Ziemlański Ś, Wartanowicz M. Rola antyoksydantów w stanie zdrowia i choroby. Pediatr. Współcz. Gastroenterol. Hepatol. Żywienie Dziecka 1999; 1(2/3): 97-105.
Clanton et al. Evidence for ROS production in skeletal muscle. P.S.E.B.M. 1999; 222: 253-262.
Sutkowy P. Wpływ jednorazowej kriostymulacji ogólnoustrojowej na stężenie dialdehydu malonowego (MDA) i drobnocząsteczkowych antyoksydantów we krwi osób amatorsko uprawiających sport. Uniwersytet Mikołaja Kopernika, Collegium Medicum im Ludwika Rydygiera w Bydgoszczy. Praca magisterska, Toruń 2010.
Schafer FQ, Buettner GR. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001; 30(11): 1191-212.
Burdon RH. Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic Biol Med 1995; 18(4): 775-794.
Suzuki YJ, Forman HJ, Sevanian A. Oxidants as stimulators of signal transduction. Free Radic Biol Med 1997; 22(1-2): 269-285.
Sun Y, Oberley LW. Redox regulation of transcriptional activators. Free Radic Biol Med 1996; 21(3): 335-348.
Allen RG, Tresini M. Oxidative stress and gene regulation. Free Radic Biol Med 2000; 28(3): 463-499.
Arrigo AP. Gene expression and the thiol redox state. Free Radic Biol Med 1999; 27(9-10): 936-944.
Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med 2000; 29(3-4): 323-333.
Gardner AM et al. Apoptotic vs. nonapoptotic cytotoxicity induced by hydrogen peroxide. Free Radic Biol Med 1997; 22(1-2): 73-83.
Vogt W. Oxidation of methionyl residues in proteins: tools, targets, and reversal. Free Radic Biol Med 1995; 18(1): 93-105.
Monteiro HP, Stern A. Redox modulation of tyrosine phosphorylation-dependent signal transduction pathways. Free Radic Biol Med 1996; 21(3): 323-333.
Sundaresan M et al. Requirement for generation of H2O2 for platelet-derived growth factor signal transduction. Science 1995; 270: 296-299.
Kamata H et al. Epidermal growth factor receptor is modulated by redox through multiple mechanisms: effects of reductants and H2O2. Eur J Biochem 2000; 267: 1933-1944.
Tonks NK. Redox redux: revisiting PTPs and the control of cell signaling. Cell 2005; 121: 667-670.
Van der Wijk T, Blanchetot C, den Hertog J. Regulation of receptor protein-tyrosine phosphatase dimerization. Methods 2005; 35: 73-79.
Czech MP, Fain JN. Cu++ - dependent thiol stimulation of glucose metabolism in white fat cells. J Biol Chem 1972; 247: 6218-6223.
Mahadev K et al. The NAD(P)H oxidase homolog Nox4 modulates insulin-stimulated generation of H2O2 and plays an integral role in insulin signal transduction. Mol Cell Biol 2004; 24: 1844-1854.
Ushio-Fukai M et al. Reactive oxygen species mediate the activation of Akt/protein kinase B by angiotensin II in vascular smooth muscle cells. J Biol Chem 1999; 274: 699-704.
Mukhin YV. 5-Hydroxytryptamine 1A receptor/gibetagamma stimulates mitogen-activated protein kinase via NAD(P)H oxidase and reactive oxygen species upstream of src in Chinese hamster ovary fibroblasts. Biochem J 2000; 347: 61-67.
Felty Q et al. Estrogen-induced mitochondrial reactive oxygen species as 1. signal-transducing messengers. Biochemistry 2005; 44: 6900-6909.
Flohé L et al. Redox regulation of NF-kappa B activation. Free Radic Biol Med 1997; 22(6): 1115-1126.
Janssen-Heininger YM, Poynter ME, Baeuerle PA. Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radic Biol Med 2000; 28(9): 1317-1327.
Rahman I, Biswas SK, Kirkham PA. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 2006; 72: 1439-1452.
Kowalczyk E i wsp. Tlenek azotu - oksydant czy antyoksydant? Wiad Lek 2005;58(9-10): 540-542.
Squadrito GL, Pryor WA. Oxidative chemistry of nitric oxide: the roles of superoxide, peroxynitrite, and carbon dioxide. Free Radic Biol Med 1998; 25(4-5): 392-403.
Klebanoff SJ. Reactive nitrogen intermediates and antimicrobial activity: role of nitrite. Free Radic Biol Med 1993; 14(4): 351-360.
Downloads
Published
How to Cite
Issue
Section
Stats
Number of views and downloads: 252
Number of citations: 0