Magnetic resonance elastography: a review
DOI:
https://doi.org/10.12775/MBS.2015.025Keywords
magnetic resonance, elastography, liver, fibrosis and cirrhosisAbstract
Magnetic Resonance Elastography (MRE) is a rapidly developing, non-invasive, precise and reproducible imaging technique used for imaging the mechanical properties of tissues and for quantitative evaluation of shear wave propagation in the examined tissues.
Magnetic resonance elastography based on three general steps, which can be described as induction of shear wave with a frequency of 50 - 5000 Hz in the tissue, then imaging of propagation of the waves inside the body (organ) using a special phase-contrast MRI technique and after all processing the acquired data in order to generate images which reveal tissue stiffness.
MRE enables detection and grading of chronic hepatic fibrosis. It can be used to monitor the response to treatment or to evaluate the progress of the disease. Attempts are made to use elastography in the assessment of different organs such as liver, heart, breast, lungs, kidneys, prostate, brain tissue and spinal cord, cartilages, muscles and bones.
References
T.C. Jacob, N.E.Penn, J.Giebink, R bastein. A comparison of breast self-examination and clinical examination. J Natl Med Assoc. Jan 1994; 86(1): 40–45.
Yin M, Chen J, Glaser KJ, Talwalkar JA, Ehman RL. Abdominal magnetic resonance elastograpfy. Topics in magnetic resonance imaging: TMRI 2009;20(2):79-87.
http://www.mayoclinic.org/magnetic-resonance-elastography
Talwalkar JA, Ehman RL, Salinas A. Needle-free liver assessment with MR elastography and ideal IQ in clinical practice. GE Healthcare MR Application Webinar.
Huwart L, Sempoux C, Vicaut E, et al. Magnetic resonance elastography for the noninvasive staging of liver fibrosis. Gastroenterology. 2008;135(1):32-40.
Rouviere O, Yin M, Dresner MA, Rossman PJ, Burgart LJ, Fidler JL, Ehman RL. MR Elastography of the Liver: Preliminary Results. Radiology. 2006; 240:440–448. [PubMed: 16864671]
Wang Y, Ganger DR, Levitsky J, et al. Assessment of chronic hepatitis and fibrosis: comparison of MR elasrography and diffusion-weighted imaging. American journal of roentgenology AJR. 2011;196(3):553-61.
Yin M, Talwalkar JA, Glaser KJ, Manduca A, Grimm RC, Rossman PJ, Fidler JL, Ehman RL. Assessment of hepatic fibrosis with magnetic resonance elastography. Clinical Gastroenterology and Hepatology. 2007; 5(10):1207–1213. [PubMed: 17916548]
Binkovitz LA, El-Youssef M, Glaser KJ, Yin M, Binkovitz AK, Ehman RL. Pediatric MR elastography of hepatic fibrosis: principles, technique and early clinical experience. Pediatric radiology. 2011.
Lee VS, Miller FH, Omary RA, et al. Magnetic resonance elastography and biomarcers to assess fibrosis from recurrent hepatitis C in liver transplant recipients. Transplantation. 2011;92(5):581-586.
Venkatesh SK, Yin M, Glockner JF, et al. MR elastography of liver tumors: preliminary results. American journal of roentgenology AJR. 2008;190(6):1534-1540.
Asbach P, Klatt D, Hamhaber U, Braun J, Somasundaram R, Hamm B, Sack I. Assessment of liver viscoelasticity using multifrequency MR elastography. Magn Reson Med. 2008; 60:373–379. [PubMed: 18666132]
Huwart L, Sempoux C, Salameh N, Jamart J, Annet L, Sinkus R, Peeters F, ter Beek LC, Horsmans Y, Van Beers BE. Liver fibrosis: noninvasive assessment with MR elastography versus aspartate aminotransferase-to-platelet ratio index. Radiology. 2007; 245:458–466. [PubMed: 17940304]
Kolipaka A, McGee KP, Araoz PA, Glaser KJ, Manduca A, Romano AJ, Ehman RL. MR elastography as a method for the assessment of myocardial stiffness: comparison with an established pressurevolume model in a left ventricular model of the heart. Magn Reson Med. 2009; 62:135–140. [PubMed: 19353657]
Sinkus R, Tanter M, Xydeas T, Catheline S, Bercoff J, Fink M. Viscoelastic shear properties of in vivo breast lesions measured by MR elastography. Magn Reson Imaging. 2005B; 23:159–165. [PubMed: 15833607]
Goss BC, McGee KP, Ehman EC, Manduca A, Ehman RL. Magnetic resonance elastography of the lung: technical feasibility. Magn Reson Med. 2006; 56:1060–1066. [PubMed: 17036283]
McGee KP, Hubmayr RD, Ehman RL. MR elastography of the lung with hyperpolarized 3He. Magnetic Resonance in Medicine. 2008; 59:14–18. [PubMed: 18058936]
Shah NS, Kruse SA, Lager DJ, Farell-Baril G, Lieske JC, King BF, Ehman RL. Evaluation of renal parenchymal disease in a rat model with magnetic resonance elastography. Magn Reson Med. 2004; 52:56–64. [PubMed: 15236367]
Chopra R, Arani A, Huang Y, Musquera M, Wachsmuth J, Bronskill M, Plewes D. In vivo MR elastography of the prostate gland using a transurethral actuator. Magn Reson Med. 2009; 62:665–671. [PubMed: 19572390]
Kemper J, Sinkus R, Lorenzen J, Nolte-Ernsting C, Stork A, Adam G. MR elastography of the prostate: initial in vivo application. RoFo; Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin. 2004; 176:1094–1099.
Kruse SA, Rose GH, Glaser KJ, Manduca A, Felmlee JP, Jack CR, Ehman RL. Magnetic resonance elastography of the brain. NeuroImage. 2008; 39:231–237. [PubMed: 17913514]
Xu L, Lin Y, Xi ZN, Shen H, Gao PY. Magnetic resonance elastography of the human brain: a preliminary study. Acta Radiol. 2007; 48:112–115. [PubMed: 17325935]
Kruse, S.; Kolipaka, A.; Manduca, A.; Ehman, R. Feasibility of Evaluating the Spinal Cord with MR Elastography. Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine; Honolulu. 2009. p. 629.
Lopez O, Amrami KK, Manduca A, Ehman RL. Characterization of the dynamic shear properties of hyaline cartilage using high-frequency dynamic MR elastography. Magnetic Resonance in Medicine. 2008; 59:356–364. [PubMed: 18228594].
Dresner MA, Rose GH, Rossman PJ, Muthupillai R, Manduca A, Ehman RL. Magnetic resonance elastography of skeletal muscle. J Magn Reson Imaging. 2001; 13:269–276. [PubMed: 11169834]
Ringleb SI, Bensamoun SF, Chen Q, Manduca A, An KN, Ehman RL. Applications of magnetic resonance elastography to healthy and pathologic skeletal muscle. J Magn Reson Imaging. 2007; 25:301–309. [PubMed: 17260391]
Chen, J.; McGregor, H.; Glaser, K.; Mariappan, Y.; Kolipaka, A.; Ehman, R. Magnetic Resonance Elastography in Trabecular Bone: Preliminary Results. Proceedings 17th Scientific Meeting, International Society for Magnetic Resonance in Medicine; Honolul. 2009. p. 847
Bae U, Dighe M, Dubinsky T, Minoshima S, Shamdasani V, Kim Y. Ultrasound thyroid elastography using carotid artery pulsation: preliminary study. Journal of Ultrasound in Medicine. 2007; 26:797–805. [PubMed: 17526611]
Kanai, H. Viscoelasticity measurement of heart wall in in vivo; Ultrasonics Symposium, 2004 IEEE; 2004. p. 482-485.
Mai JJ, Insana MF. Strain imaging of internal deformation. Ultrasound in Medicine and Biology. 2002; 28:1475–1484. [PubMed: 12498943]
Bercoff J, Tanter M, Fink M. Supersonic shear imaging: a new technique for soft tissue elasticity mapping. Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on. 2004; 51:396–409.
Osman NF. Detecting stiff masses using strain-encoded (SENC) imaging. Magnetic Resonance in Medicine. 2003; 49:605–608. [PubMed: 12594769]
Ophir J, cespedes I, Ponnekanti H, Yazdi Y, Li X. Elastography : a quantitative method for imaging the elasticity of biological tissues. Ultrason Imaging. 1991; 13(2):111–134. [PubMed: 1858217]
Chenevert TL, Skovoroda AR, O'Donnell M, Emelianov SY. Elasticity reconstructive imaging by means of stimulated echo MRI. Magnetic Resonance in Medicine. 1998; 39:482–490. [PubMed:9498605]
Steele DD, Chenevert TL, Skovoroda AR, Emelianov SY. Three-dimensional static displacement, stimulated echo NMR elasticity imaging. Physics in Medicine and Biology. 2000; 45:1633–1648. [PubMed: 10870715]
Lerner RM, Huang SR, Parker KJ. 'Sonoelasticity' images derived from ultrasound signals in mechanically vibrated tissues. Ultrasound in Medicine and Biology. 1990; 16:231–239. [PubMed:1694603]
Levinson SF, Shinagawa M, Sato T. Sonoelastic determination of human skeletal-muscle elasticity. Journal of Biomechanics. 1995; 28:1145–1154. [PubMed: 8550633]
Muthupillai R, Lomas DJ, Rossman PJ, Greenleaf JF, Manduca A, Ehman RL. Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. Science. 1995; 269:1854–1857. [PubMed: 7569924]
Sack I, Mcgowan CK, Samani A, Luginbuhl C, Oakden W, Plewes DB. Observation of nonlinear shear wave propagation using magnetic resonance elastography. Magnetic Resonance in Medicine. 2004; 52:842–850. [PubMed: 15389935]
Sinkus, R.; Lorenzen, J.; Schrader, D.; Lorenzen, M.; Dargatz, M.; Holz, D. In vivo tensor Mr-elastography - anisotropy of mamma-carcinoma. Proceedings of the International Society for Magnetic Resonance in Medicine; Denver, Colorado. 2000. p. 493
Gierke HE, Oestreicher HL, Franke EK, Parrack HO, Wittern WW. Physics of vibrations in living tissues. J Appl Physiol. 1952; 4:886–900. [PubMed: 14946086]
Rogowska J, Patel NA, Fujimoto JG, Brezinski ME. Optical coherence tomographic elastography technique for measuring deformation and strain of atherosclerotic tissues. Heart. 2004; 90:556–562. [PubMed: 15084558]
Ruikang KW, Zhenhe M, Sean JK. Tissue Doppler optical coherence elastography for real time strain rate and strain mapping of soft tissue. Applied Physics Letters. 2006; 89:144103.
van Soest G, Mastik F, de Jong N, van der Steen AF. Robust intravascular optical coherence elastography by line correlations. Phys Med Biol. 2007; 52:2445–2458. [PubMed: 17440245]
Egorov V, Ayrapetyan S, Sarvazyan AP. Prostate mechanical imaging: 3-D image composition and feature calculations. Medical Imaging, IEEE Transactions on. 2006; 25:1329–1340.
Sarvazyan A. Mechanical imaging - a new technology for medical diagnostics. International Journal of Medical Informatics. 1998; 49:195–216. [PubMed: 9741894]
de Ledinghen V, Le Bail B, Rebouissoux L, Fournier C, Foucher J, Miette V, Castera L, Sandrin L, Merrouche W, Lavrand F, Lamireau T. Liver stiffness measurement in children using FibroScan: feasibility study and comparison with fibrotest, aspartate transaminase to platelets ratio index, and liver biopsy. Journal of Pediatric Gastroenterology and Nutrition. 2007; 45:443–450. [PubMed: 18030211]
Sandrin L, Fourquet B, Hasquenoph JM, Yon S, Fournier C, Mal F, Christidis C, Ziol M, Poulet B, Kazemi F, Beaugrand M, Palau R. Transient elastography: a new noninvasive method for assessment of hepatic fibrosis. Ultrasound Med Biol. 2003; 29:1705–1713. [PubMed: 14698338]
Mariappan YK, Glaser KJ, Ehman RL. Magnetic resonance elastography: a review. Clin Anat. 2010;23(5):497-511.
Talwalkar JA. Elastography for detecting hepatic fibrosis: options and considerations. Gastroenterology. 2008;135(1):299-302.
Talwalkar JA, Kurtz DM, Schoenleber SJ, West CP, Montori VM. Ultrasound-based transient elastography for the detection of hepatic fibrosis: systematic review and meta-analysis. Clinical gastroenterology and hepatology. 2007;5(10):1214-1220.
Axel L, Dougherty L. MR imaging of motion with spatial modulation of magnetization. Radiology. 1989; 171:841–845. [PubMed: 2717762]
Zerhouni EA, Parish DM, Rogers WJ, Yang A, Shapiro EP. Human heart: tagging with MR imaging - a method for noninvasive assessment of myocardial motion. Radiology. 1988; 169:59–63. [PubMed: 3420283]
Muthupillai R, Rossman PJ, Lomas DJ, Greenleaf JF, Riederer SJ, Ehman RL. Magnetic resonance imaging of transverse acoustic strain waves. Magnetic Resonance in Medicine. 1996; 36:266–274. [PubMed: 8843381]
O'Donnell M, Skovoroda AR, Shapo BM, Emelianov SY. Internal displacement and strain imaging using ultrasonic speckle tracking. Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on. 1994; 41:314-325.
Venkatesh, SK.; Yin, M.; Talwalkar, JA.; Ehman, RL. Application of liver MR elastography in clinical practice. Proceedings of the International Society for Magnetic Resonance in Medicine; Toronto, Ontario, Canada. 2008b. p. 2611.
Ehman EC, Rossman PJ, Kruse SA, Sahakian AV, Glaser KJ. Vibration safety limits for magnetic resonance elastography. Phys Med Biol. 2008; 53:925–935. [PubMed: 18263949]
Tse ZT, Janssen H, Hamed A, Ristic M, Young I, Lamperth M. Magnetic resonance elastography hardware design: a survey. Proc Inst Mech Eng H. 2009; 223:497–514. [PubMed: 19499839]
Moran PR. A flow velocity zeugmatographic interlace for NMR imaging in humans. Magn Reson Imaging. 1982; 1:197–203. [PubMed: 6927206]
Bieri O, Maderwald S, Ladd ME, Scheffler K. Balanced alternating steady-state elastography. Magnetic Resonance in Medicine. 2006; 55:233–241. [PubMed: 16416431]
Kruse, SA.; Grimm, RC.; Lake, DS.; Manduca, A.; Ehman, RL. Fast EPI based 3D MR elastography of the brain. Proceedings of the International Society for Magnetic Resonance in Medicine; Seattle, Washington. 2006. p. 3385
Maderwald S, Uffmann K, Galban CJ, de Greiff A, Ladd ME. Accelerating MR elastography: a multiecho phase-contrast gradient-echo sequence. Journal of Magnetic Resonance Imaging. 2006; 23:774–780. [PubMed: 16570244]
Rydberg, J.; Grimm, R.; Kruse, S.; Felmlee, J.; McCracken, P.; Ehman, R. Fast spin-echo magnetic resonance elastography of the brain. Proceedings of the International Society for Magnetic Resonance in Medicine; Glasgow, Scotland: International Society for Magnetic Resonance in Medicine; 2001. p. 1647
Manduca A, Oliphant TE, Dresner MA, Mahowald JL, Kruse SA, Amromin E, Felmlee JP, Greenleaf JF, Ehman RL. Magnetic resonance elastography: non-invasive mapping of tissue elasticity. Med Image Anal. 2001; 5:237–254. [PubMed: 11731304]
Manduca, A.; Muthupillai, R.; Rossman, PJ.; Greenleaf, JF.; Ehman, RL. Local wavelength estimation for magnetic resonance elastography. Image Processing, 1996. Proceedings., International Conference on; 1996. p. 527-530.
Oliphant TE, Manduca A, Ehman RL, Greenleaf JF. Complex-valued stiffness reconstruction for magnetic resonance elastography by algebraic inversion of the differential equation. Magn Reson Med. 2001; 45:299–310. [PubMed: 11180438]
Faria SC, Ganesan K, Mwangi I, Shiehmorteza M, Viamonte B, Mazhar S, Peterson M, Kono Y, Santillan C, Casola G, Sirlin CB. MR imaging of liver fibrosis: current state of the art. Radiographics. 2009; 29:1615–1635. [PubMed: 19959511]
Talwalkar JA, Yin M, Fidler JL, Sanderson SO, Kamath PS, Ehman RL. Magnetic resonance imaging of hepatic fibrosis: emerging clinical applications. Hepatology. 2008; 47:332–342. [PubMed: 18161879]
Fassio E, Alvarez E, Dominguez N, Landeira G, Longo C. Natural history of nonalcoholic steatohepatitis: a longitudinal study of repeat liver biopsies. Hepatology. 2004;40(4):820-826.
Salameh N, Larrat B, Abarca-Quinones j, et al. Early detection of steatohepatitis in fatty rat liver by using MR elastography. Radiology 2009;253(1):90-97
Willatt JM, Hussain HK, Adusumilli S, Marrero JA. MR imaging of hepatocellular carcinoma in the cirrhotic liver: challenges and controversies. Radiology. 2008;247(2):311-330.
Sudharshan Parthasarathy, et al. Magnetic resonance elastography: proven indications, challenges and future considerations. Magnetom Flash. 2012;1:20-27.
Taouli B, Ehman RL, Reeder SB. Advanced MRI methods for assessment of chronic liver disease. American journal of roentgenology. 2009;193(1):14-27
Bravo AA, Sheth SG, Chora S: Liver biopsy. N Eng J Med, 2001; 344: 495–500.
Grant A, Neuberger J: Guidelines on the use of liver biopsy in clinical practice. Gut, 1999; 45(Suppl.IV): IV1–IV11.
Regev A, Berho M, Jeffers LJ, et al. Sampling error and intraobserver variation in liver biopsy in patient with chronic HCV infection. The American journal of gastroenterology. 2002;97(10):2614-2618.
Rustogi R, Horowitz J, Harmath C, et al. Accuracy of MR elastography and anatomic MR imaging features in the diagnosis of severe hepatic fibrosis and cirrhosis. JMRI. 2012.
Kim BH, Lee JM, Lee YJ, et al. MR elastography for noninvasive assessment of hepatic fibrosis: experience from a tertiary center in Asia. JMRI 2011;34(5):1110-1116.
Yi Wang, Daniel R.Ganger, Josh Levitsky et al. Assessment of Chronic Hepatitis and Fibrosis: Comparison of Magnetic Resonance Elastography (MRE) and Diffusion-weighted Imaging (DWI). AJR Am J Roentgenol. Mar 2011; 196(3): 553-561.
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