Effect od a single dose of Methadone on saccadic refixations in Opioid addicted subjects
DOI:
https://doi.org/10.12775/MBS.2014.002Keywords
opiates, methadone, saccadic refi xation, saccades HIVAbstract
Introduction: Eye movements are closely related to cognitive and emotional functions. Information on saccadic dynamics during certain tasks may indicate disorders of mental functions, which can help to explain the neurobiology of sensory-motor systems and can be useful in neuropsychiatric diagnosis. Aims/ Objectives: The study aims at assessing the impact of a single therapeutic dose of methadone on eye movements (saccades) dynamics in HIV(+) and HIV(-) opioid addicted subjects. Methods: Sixty patients from the substitution program were examined. The Latency Test (LT), carried out with the use of saccadometer diagnostic system, was conducted twice: before and 1.5 hours after the administration of a therapeutic dose of methadone. In both parts of the test mean peak velocity, mean latency, mean duration, mean amplitude were measured. Results: The mean duration of latency in HIV(-) subjects measured by LT after the administration of a therapeutic dose of methadone was statistically significantly increased whereas the mean peak velocity was decreased. The mean peak velocity latency in HIV(+) subjects is not statistically significant. The mean duration and the amplitude of latency after the administration of a therapeutic dose of methadone is statistically significant in opioid addicted HIV(+) subjects . It was found that the mean peak velocity before the administration of a therapeutic dose of methadone was statistically significantly different in HIV(-) subjects as compared to HIV(+) ones. Conclusion: An increase in the values of saccadic refixation parameters in opioid addicted subjects after the administration of a therapeutic dose of methadone was observed. An improvement in saccadic refixations parameter in HIV(-) subjects after the administration of a therapeutic dose of methadone was concluded.
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